{"id":42537,"date":"2022-04-01T07:26:44","date_gmt":"2022-04-01T07:26:44","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=42537"},"modified":"2022-04-01T20:57:18","modified_gmt":"2022-04-01T20:57:18","slug":"south-africa-approves-dapivirine-vaginal-ring-for-hiv-prevention","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/42537","title":{"rendered":"South Africa approves dapivirine vaginal ring for HIV prevention"},"content":{"rendered":"
\n

Simon Collins, HIV i-Base<\/strong><\/p>\n<\/div>\n

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On 11 March 2022, the South African regulatory authority (SAHPRA) approved a monthly vaginal ring for use by adult women to protect against sexual transmission of HIV. [1]<\/span><\/strong><\/p>\n<\/div>\n

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This is approximately 18 months after the EMA issued a positive opinion supportive approval in countries with high HIV incidence. [2]<\/span><\/p>\n<\/div>\n

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The press release from the <\/span>International Partnership for Microbicides (IPM) emphasises the high need for better options for women and the advantages of the formulation that is easy to self-administer.<\/p>\n<\/div>\n

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But it also notes that efficacy is significantly lower that other methods of PrEP.<\/p>\n<\/div>\n

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The two phase 3 studies supporting approval reported overall efficacy rates of only 31% and 27% in the Ring and ASPIRE studies respectively. Subgroup and post-hoc analyses showed higher efficacy with greater adherence, as with other PrEP studies, and that this was higher in older women. [3, 4, 5]<\/p>\n<\/div>\n

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References<\/span><\/p>\n<\/div>\n

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    \n
  1. IMP press statement. South Africa approves dapivirine vaginal ring for use by women. (11 March 2022).
    \n<\/span>https:\/\/www.ipmglobal.org\/content\/south-africa-approves-dapivirine-vaginal-ring-use-women<\/a><\/li>\n
  2. EMA supports use of dapivirine vaginal ring to prevent HIV in high-incidence countries. HTB (August 2020).
    \n    https:\/\/i-base.info\/htb\/38818<\/a><\/li>\n
  3. IMP press statement. Two large studies show IPM\u2019s monthly vaginal ring helps protect women against HIV. (22 February 2016).
    \n    https:\/\/www.ipmglobal.org\/publications\/two-large-studies-show-ipm\u2019s-monthly-vaginal-ring-helps-protect-women-against-hiv<\/a><\/li>\n
  4. Baeten JM et al. Use of a vaginal ring containing dapivirine for HIV-1 prevention in women.\u00a0N Engl J Med\u00a02016;375:2121-2132.
    \n    https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1506110<\/a><\/li>\n
  5. Nel A et al. Safety and efficacy of a dapivirine vaginal ring for HIV prevention in women.\u00a0N Engl J Med\u00a02016;375:2133-2143.
    \n    https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1602046<\/a><\/li>\n<\/ol>\n

    This report was first published on 16 March 2022.<\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Simon Collins, HIV i-Base On 11 March 2022, the South African regulatory authority (SAHPRA) approved a monthly vaginal ring for use by adult women to protect against sexual transmission of HIV. [1] This is approximately 18 months after the EMA …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[],"class_list":["post-42537","post","type-post","status-publish","format-standard","hentry","category-transmission-and-prevention"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/42537","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=42537"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/42537\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=42537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=42537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=42537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}