{"id":42568,"date":"2022-04-01T07:40:19","date_gmt":"2022-04-01T07:40:19","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=42568"},"modified":"2022-09-12T07:38:32","modified_gmt":"2022-09-12T07:38:32","slug":"croi-2022-long-covid-persists-for-over-a-year-evidence-for-divergent-immune-responses","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/42568","title":{"rendered":"CROI 2022: Long COVID persists for over a year: evidence for divergent immune responses"},"content":{"rendered":"

Kirk Taylor, HIV i-Base<\/strong><\/p>\n

\"CROIApproximately 20% of the studies at CROI 2022 had a link to COVID-19, included several focused on long COVID (PASC).<\/strong><\/p>\n

A French cohort study reported persistence of COVID symptoms a year after hospital admission that was was more common in women than men with 25% of people not returning to work after a year. [1]<\/p>\n

Another study differentiated people with long COVID by antibody responses, although the clinical impact this has on disease progression was unclear. [2]<\/p>\n

Persistent COVID symptoms 12 months post-hospital admission<\/h2>\n

A prospective cohort study followed people hospitalised with COVID (n=737) for a year after admission.<\/p>\n

Participants were male (64%) with median age of 61 years (IQR: 51 to 70), 37% had been admitted to ICU and 27% had \u22653 symptoms at 12 months.<\/p>\n

Follow-up visits were conducted at 3, 6 and 12 months post-admission. Participant interviews assessed quality of life, COVID symptoms and psychological distress. The most reported symptoms were fatigue (46%), shortness of breath (33%) and joint pain (21%).<\/p>\n

Overall, 25% of participants had not returned to work after a year. This was more common for women (34%) than men (24%). Women also reported more COVID symptoms, depression, and anxiety.<\/p>\n

Differential antibody responses of people with long COVID<\/h2>\n

Antibody responses were evaluated from people with long COVID who had persistent or resurgent symptoms three months post-infection. [2]<\/p>\n

Participants either had long COVID (n=44), had recovered from COVID (n=25) or were uninfected (n=14).<\/p>\n

Anti-COVID spike IgG and IgA antibody titres were measured and 48% of long COVID patients were seropositive. Seropositive patients had increased T Cell responses to inflammatory stimuli and COVID proteins in vitro. The seronegative group responses were not statistically different to people who had recovered.<\/p>\n

These data show differences in the adaptive immune responses of people with long COVID that might help to understand reasons for disease persistence and potential therapies.<\/p>\n

comment<\/h3>\n

Long COVID is now a well-established complication that is complicated by very diverse symptoms and the lack of a single mechanism or simple diagnostic test,<\/strong><\/p>\n

These studies highlight the persistence of COVID symptoms and associated quality of life implications. <\/strong><\/p>\n

Kervevan and colleagues report divergent antibody responses that map to altered T cell responses but their study does not describe how these findings relate to disease progression or severity.<\/strong><\/p>\n

Further studies are required to understand the aetiology of long COVID and identify potential risk factors to facilitate clinical management.<\/strong><\/p>\n

The UK 100-page guidelines on late COVID were recently updated by NICE, the Scottish Intercollegiate Guidelines Network (SIGN) and the Royal College of General Practitioners (RCGP). [3]<\/strong><\/p>\n

These guidelines were also previously criticised for a limited focus on potential causes and the range of symptoms and for minimal involvement of people living with long COVID. [4]<\/strong><\/p>\n

References<\/p>\n

    \n
  1. Chirouze C et al. Persistent COVID-19 symptoms are highly prevalent 12 months after hospitalisation. CROI 2022. 12-16 February 2022, virtual. Poster 628.
    \nhttps:\/\/www.croiconference.org\/abstract\/persistent-covid-19-symptoms-are-highly-prevalent-12-months-after-hospitalization\/<\/a><\/li>\n
  2. Kervevan et al. Divergent adaptive immune responses define two types of long covid. CROI 2022. 12-16 February 2022, virtual. Poster 322.
    \n    https:\/\/www.croiconference.org\/abstract\/divergent-adaptive-immune-responses-define-2-types-of-long-covid\/<\/a><\/li>\n
  3. NICE et al. COVID-19 rapid guideline: managing the long- term effects of COVID-19. (3 March 2022).
    \n    https:\/\/www.nice.org.uk\/guidance\/ng188\/resources\/covid19-rapid-guideline-managing-the-longterm-effects-of-covid19-pdf-51035515742<\/a><\/li>\n
  4. Gorna R et al. Long COVID-19 guidelines need to reflect lived experience. Lancet. 2021; 397: 455-457.
    \n    https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(20)32705-7\/fulltext<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Kirk Taylor, HIV i-Base Approximately 20% of the studies at CROI 2022 had a link to COVID-19, included several focused on long COVID (PASC). A French cohort study reported persistence of COVID symptoms a year after hospital admission that was …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,31,311,278],"tags":[318],"class_list":["post-42568","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-opportunistic-infections-coinfections-and-complications","category-long-covid","category-covid-19","tag-croi-2022"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/42568","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=42568"}],"version-history":[{"count":1,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/42568\/revisions"}],"predecessor-version":[{"id":44053,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/42568\/revisions\/44053"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=42568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=42568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=42568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}