{"id":42574,"date":"2022-04-01T07:44:31","date_gmt":"2022-04-01T07:44:31","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=42574"},"modified":"2022-09-12T07:38:10","modified_gmt":"2022-09-12T07:38:10","slug":"croi-2022-uk-study-reports-diabetes-mellitus-in-9-of-hiv-positive-africans-in-the-uk-on-stable-art","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/42574","title":{"rendered":"CROI 2022: UK study reports diabetes mellitus in 9% of HIV positive Africans in the UK on stable ART"},"content":{"rendered":"

Kirk Taylor, HIV i-Base<\/strong><\/p>\n

\"CROICROI 2022 included a UK study looking at the prevalence of diabetes mellitus (DM) in HIV positive Africans on ART. [1]<\/strong><\/p>\n

The GEN-AFRICA cross-sectional cohort study enrolled HIV positive participants that attended 15 UK clinics between 2018 to 2020 and evaluated risk factors for DM.<\/p>\n

Participants (n=2,308) were from West (36%), East (33%), South (24%) or Central Africa (7%), were female (62%) and heterosexual (87%). HIV was well managed with 99% on ART, viral load of <200 copies\/mL (94%) and median CD4 count of 556 cells\/mm3<\/sup> (IQR 409 to 721). Mean age was 48.0 years [SD 9.9].<\/p>\n

Common comorbidities were obesity (44%), hypertension (31%), and proteinuria (22%), whilst only 4% had cardiovascular disease. Type 2 diabetes was reported for 9% (n=216) and was most common in participants over 50 (72%).<\/p>\n

DM and obesity increased with age but the association between DM and obesity was lost after multivariate analysis. Female participants were more likely to be obese (52% vs 31%, p<0.001), but males were more likely to have DM (12.8% vs 7.4%, p<0.001).<\/p>\n

The authors emphasise the importance of routinely screening HIV positive Africans for DM, especially if they are older than 40.<\/p>\n

comment<\/h3>\n

These data highlight associations between HIV, age and obesity and diabetic risk. The a<\/strong>pproximate prevalence of DM is about 6% in the UK general population, which will be older than an HIV cohort, but also likely to be less engaged in care.<\/b><\/p>\n

However, this was a small cross-sectional sample and longitudinal data are needed to further understand diabetic risk in HIV positive African populations.<\/strong><\/p>\n

Associations between DM and obesity in this study are limited by use of BMI measurements rather than measures of central obesity. <\/strong><\/p>\n

Earlier studies have reported that HIV is associated with higher rates of DM than the general population, and that this also increases with age. [2]<\/strong><\/p>\n

These results highlight the importance of the BHIVA recommendation for baseline assessment for diabetes and annual metabolic assessment including HbA1c and lipid profile if aged >40 years. [3]<\/strong><\/p>\n

References<\/p>\n

    \n
  1. Hardy G. Increased prevalence of diabetes in HIV positive people. HTB (26 June 2017).
    \nhttps:\/\/i-base.info\/htb\/31692<\/a><\/li>\n
  2. Hamzah et al. Age and obesity as risk factors for diabetes in Africans with HIV. CROI 2022. February 12-16, virtual. Poster 604
    \n    https:\/\/www.croiconference.org\/abstract\/age-and-obesity-as-risk-factors-for-diabetes-in-africans-with-hiv\/<\/a><\/li>\n
  3. BHIVA. BHIVA guidelines for the routine investigation and monitoring of adult HIV-1-positive individuals 2016 (2019 interim update).
    \n    https:\/\/www.bhiva.org\/monitoring-guidelines<\/a><\/li>\n<\/ol>\n

    This report was first published on 20 March 2022.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

    Kirk Taylor, HIV i-Base CROI 2022 included a UK study looking at the prevalence of diabetes mellitus (DM) in HIV positive Africans on ART. [1] The GEN-AFRICA cross-sectional cohort study enrolled HIV positive participants that attended 15 UK clinics between …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,31],"tags":[318],"class_list":["post-42574","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-opportunistic-infections-coinfections-and-complications","tag-croi-2022"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/42574","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=42574"}],"version-history":[{"count":1,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/42574\/revisions"}],"predecessor-version":[{"id":44051,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/42574\/revisions\/44051"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=42574"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=42574"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=42574"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}