{"id":4279,"date":"2001-04-17T20:55:17","date_gmt":"2001-04-17T20:55:17","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=4279"},"modified":"2014-06-12T14:08:31","modified_gmt":"2014-06-12T14:08:31","slug":"ctls-decrease-with-combination-antiretroviral-therapy-but-precursor-cells-remain","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/4279","title":{"rendered":"CTLs decrease with combination antiretroviral therapy but precursor cells remain"},"content":{"rendered":"<p><strong>While combination antiretroviral therapy is associated with a decrease in activated cytotoxic T lymphocytes (CTLs), precursor cells remain, and recognition of new viral epitopes may occur, according to a report published in the March issue of the Journal of Infectious Diseases.<\/strong><\/p>\n<p>Dr. M. Juliana McElrath, from the Fred Hutchinson Cancer Research Center, in Seattle, and colleagues studied the evolution of T-cell phenotypes and HIV-specific CD8+ lymphocytes in 41 HIV-infected patients who began combination antiretroviral therapy.<\/p>\n<p>The authors found that naive CD8+ T cells increased and activated CD8+ T cells decreased when viral loads were suppressed to less than 200 copies\/mL. CTL precursor frequencies were comparable before and after treatment, the investigators state. In addition, 8 of 11 CTL precursors appeared capable of a new or increased response after treatment.<\/p>\n<p>&#8220;Our findings suggest that, even if the memory CD8+ CTL pool is sustained, this immune defence alone will not be adequate to control HIV-1 infection once one or two of the antiretroviral agents are subsequently stopped,&#8221; the researchers note.<\/p>\n<p>Dr. McElrath&#8217;s group believes, however, that &#8220;future studies may delineate chronically infected patients in whom therapy cessation is more feasible, on the basis of a sustained memory CTL pool, in addition to new epitope recognition, perhaps in conjunction with improved T-cell help in chronically infected patients.&#8221;<\/p>\n<p>Reference:<\/p>\n<p>J Infect Dis 2001;183:722-729. Source: Reuters Health<\/p>\n","protected":false},"excerpt":{"rendered":"<p>While combination antiretroviral therapy is associated with a decrease in activated cytotoxic T lymphocytes (CTLs), precursor cells remain, and recognition of new viral epitopes may occur, according to a report published in the March issue of the Journal of Infectious &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"class_list":["post-4279","post","type-post","status-publish","format-standard","hentry","category-basic-science-and-immunology"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4279","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=4279"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4279\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=4279"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=4279"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=4279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}