{"id":43206,"date":"2022-07-01T07:22:11","date_gmt":"2022-07-01T07:22:11","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=43206"},"modified":"2022-07-01T08:35:05","modified_gmt":"2022-07-01T08:35:05","slug":"us-study-reports-higher-rates-of-breakthrough-covid-in-hiv-positive-vs-negative-controls","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/43206","title":{"rendered":"US study reports higher rates of breakthrough COVID in HIV positive vs negative controls"},"content":{"rendered":"
Kirk Taylor, HIV i-Base<\/span><\/strong><\/div>\n
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A large US cohort study reported that although rate of breakthrough infections were generally low, this was 28% higher in people living with HIV.\u00a0<\/span><\/strong><\/p>\n<\/div>\n

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The study, published in JAMA matched controls (n=80,965) 3:1 to HIV positive people (n=33,029) and compared incidence of COVID-19 following vaccination. <\/span><\/p>\n<\/div>\n

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The incident rate for breakthrough cases (per 1,000 person years) was 55 (95% CI: 52 to 58) vs 43 (95% CI; 42 to 45) in HIV positive vs negative controls.<\/span><\/p>\n<\/div>\n

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Participants were well matched between groups and were male (92%), White (38%), Black (41%), Hispanic (13%) and Asian (3.4%), 70% were aged \u226555 (range: 18 to \u226575) and 98% received mRNA vaccines.\u00a0 <\/span><\/p>\n<\/div>\n

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HIV was well controlled with 91% <50 copies\/mL and CD4 counts of 636 cells\/mm3<\/sup> (95% CI: 449 to 858) after full vaccination. Nadir CD4 counts were 636 cells\/mm3<\/sup> (95% CI: 202 to 584). <\/span><\/p>\n<\/div>\n

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Breakthrough cases were lower for people with HIV aged \u226555 who received mRNA vaccines and for those with CD4 counts \u2265500 cells\/mm3<\/sup>. There were no differences is risk of severe illness between the two groups.<\/span><\/p>\n<\/div>\n

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Cases were more common for people that received adenoviral vaccine this only represented 2% of participants.<\/p>\n<\/div>\n

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comment<\/span><\/h3>\n<\/div>\n
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Breakthrough COVID-19 cases following vaccination account for a small percentage of all cases in the USA. Many studies have now reported comparable immune responses for people with HIV with good CD4 counts on ART. <\/span><\/b><\/p>\n<\/div>\n

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The authors report associations between CD4 counts below 200 cells\/mm3<\/sup> and greater incidence of breakthrough COVID-19. However, it is unlikely the present study was sufficiently powered to detect associations between CD4 counts and COVID-19 cases.<\/b><\/p>\n<\/div>\n

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References<\/span><\/p>\n<\/div>\n

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Coburn SB et al. Analysis of postvaccination breakthrough COVID-19 infections among adults with HIV in the United States. JAMA. DOI:10.1001\/jamanetworkopen.2022.15934 (07 June 2022).
\n<\/span>https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2793102<\/a><\/p>\n

This report was first published on 26 June 2022.<\/em><\/p>\n<\/div>\n

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\u00a0<\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Kirk Taylor, HIV i-Base A large US cohort study reported that although rate of breakthrough infections were generally low, this was 28% higher in people living with HIV.\u00a0 The study, published in JAMA matched controls (n=80,965) 3:1 to HIV positive …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[31,282,292,278],"tags":[],"class_list":["post-43206","post","type-post","status-publish","format-standard","hentry","category-opportunistic-infections-coinfections-and-complications","category-covid-19-hiv-and-covid-19-coinfection","category-covid-19-vaccine","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/43206","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=43206"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/43206\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=43206"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=43206"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=43206"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}