{"id":43232,"date":"2022-07-01T07:25:49","date_gmt":"2022-07-01T07:25:49","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=43232"},"modified":"2022-07-01T08:36:15","modified_gmt":"2022-07-01T08:36:15","slug":"importance-of-booster-vaccine-to-protect-against-emergent-covid-19-strains","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/43232","title":{"rendered":"Importance of booster vaccine to protect against emergent COVID-19 variants"},"content":{"rendered":"
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Kirk Taylor, HIV i-Base<\/strong><\/p>\n<\/div>\n

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A small study showing the importance of booster vaccination to protect against COVID-19 variants by researchers from Ohio University was published as a letter in the 15 June edition of the NEJM. [1] <\/span><\/strong><\/p>\n<\/div>\n

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Neutralising antibody (nAb) titres against different COVID-19 strains were analysed from stored serum samples. Participants were healthcare workers that had been triple vaccinated with Moderna (n=4) or Pfizer (n=11) mRNA vaccines. Additional samples from people admitted to ICU during the delta wave (n=18) or hospitalised during omicron wave (n=30) were also studied. <\/span><\/p>\n<\/div>\n

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Compared to the D416G COVID-19 strain, nAb titres were 4.1-fold and 3.2-fold lower against BA.4\/5 and BA.2.12.1 variants, respectively (p<0.001).<\/span><\/p>\n<\/div>\n

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Overall, nAb titres against emergent strains were lowest in twice vaccinated participants. Boosting or previous COVID-19 disease generated greater levels of nAbs compared to unboosted individuals. <\/span><\/p>\n<\/div>\n

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comment<\/span><\/h3>\n<\/div>\n
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This is a short letter to NEJM that concerns an important topic, but it is important to note that the sample sizes are low.<\/span><\/strong><\/p>\n<\/div>\n

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Boosting of immune responses following COVID-19, is strain-dependent. A study of 700 triple vaccinated healthcare workers in the UK reports that immune boosting is lower for omicron than compared to other variants. [2] <\/span><\/strong><\/p>\n<\/div>\n

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These data highlight the importance of receiving COVID-19 boosters as required by local vaccination programmes.<\/span><\/strong><\/p>\n<\/div>\n

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References<\/span><\/p>\n<\/div>\n

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  1. Qu P et al. Neutralization of the SARS-CoV-2 omicron BA.4\/5 and BA.2.12.1 subvariants. NEJM. DOI: 10.1056\/NEJMc2206725 (15 Jun 2022).
    \n<\/span>https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMc2206725<\/a><\/li>\n
  2. Reynolds CJ et al. Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure. Science. DOI: 10.1126\/science\/abq1841 (14 Jun 2022).
    \n    https:\/\/www.science.org\/doi\/10.1126\/science.abq1841<\/a><\/li>\n<\/ol>\n

    This report was first published on 26 June 2022.<\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Kirk Taylor, HIV i-Base A small study showing the importance of booster vaccination to protect against COVID-19 variants by researchers from Ohio University was published as a letter in the 15 June edition of the NEJM. [1] Neutralising antibody (nAb) …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[31,292,278],"tags":[],"class_list":["post-43232","post","type-post","status-publish","format-standard","hentry","category-opportunistic-infections-coinfections-and-complications","category-covid-19-vaccine","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/43232","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=43232"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/43232\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=43232"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=43232"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=43232"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}