{"id":4353,"date":"2001-05-17T22:26:54","date_gmt":"2001-05-17T22:26:54","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=4353"},"modified":"2014-06-12T13:43:23","modified_gmt":"2014-06-12T13:43:23","slug":"patient-age-influences-cd4-cell-recovery-with-haart","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/4353","title":{"rendered":"Patient age influences CD4+ cell recovery with HAART"},"content":{"rendered":"<p><strong>Younger HIV-infected patients who receive highly active antiretroviral therapy (HAART) achieve a more rapid and greater CD4+ cell response than older patients receiving HAART, according to a report published in the April 15th issue of the Journal of Infectious Diseases.<\/strong><\/p>\n<p>Dr. Jean-Paul Viard from Hopital Necker in Paris and colleagues studied the effect of age on CD4+ cell response to HAART in 1956 HIV-infected patients who participated in the EuroSIDA study. All subjects were at least 16 years of age and the median age was 37.2 years. The median follow-up period was 31 months.<\/p>\n<p>The median initial CD4+ cell count was 192 cells\/\u00b5L and did not differ significantly based on patient age. Furthermore, baseline HIV RNA load and treatment history were also not linked to patient age, the authors state.<\/p>\n<p>Overall, the median time to maximum CD4+ cell response was 20 months. However, CD4+ cell increase, maximum CD4+ cell increase, and maximum CD4+ cell count did show a significant inverse relationship with patient age. The inverse relationship between age and maximum CD4+ cell response was confirmed on multivariate analysis, the researchers note.<\/p>\n<p>The investigators found that the time needed to achieve a CD4+ cell increase of &gt;200 cells\/\u00b5L was directly associated with patient age.<\/p>\n<p>&#8220;Quantitative CD4+ cell response to HAART is variable and not fully explained,&#8221; the researchers state. &#8220;The favourable influence of younger age on CD4+ cell recovery while a patient is receiving HAART may be explained by more effective thymic function,&#8221; they add.<\/p>\n<p>&#8220;The present findings confirm that renewal of CD4+ cells is a long-term process and demonstrate that age is inversely correlated with the magnitude and speed of CD4+ cell recovery in actively treated HIV infection,&#8221; the authors note. &#8220;These are additional arguments for the involvement of renewed lymphopoiesis in CD4+ cell reconstitution.&#8221;<\/p>\n<p>Reference:<\/p>\n<p>J Infect Dis 2001;183:1290-1294.<\/p>\n<p>Source: Reuters Health<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Younger HIV-infected patients who receive highly active antiretroviral therapy (HAART) achieve a more rapid and greater CD4+ cell response than older patients receiving HAART, according to a report published in the April 15th issue of the Journal of Infectious Diseases. &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-4353","post","type-post","status-publish","format-standard","hentry","category-antiretrovirals"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4353","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=4353"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4353\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=4353"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=4353"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=4353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}