{"id":43648,"date":"2022-08-03T07:14:56","date_gmt":"2022-08-03T07:14:56","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=43648"},"modified":"2022-08-04T08:41:14","modified_gmt":"2022-08-04T08:41:14","slug":"accumulating-sars-cov-2-mutations-in-prolonged-covid-19-in-advanced-hiv-off-art-simon-collins-hiv-i-base-this-paper-includes-a-case-report-that-tracks-the-accumulation-of-more-than-20-key-mutations-i","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/43648","title":{"rendered":"Accumulating SARS-CoV-2 mutations in prolonged COVID-19 in advanced HIV off-ART"},"content":{"rendered":"<div>\n<p class=\"HTBsubhead2articletitle\"><strong>Kirk Taylor, HIV i-Base<\/strong><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><strong><span lang=\"EN-US\"><img loading=\"lazy\" decoding=\"async\" class=\" alignright\" src=\"https:\/\/i-base.info\/wp-content\/uploads\/2020\/03\/COVID-19-graphic.png\" width=\"231\" height=\"142\" \/>This paper includes a case report that tracks the accumulation of more than 20 key mutations in an HIV positive person with prolonged COVID-19.<\/span><\/strong><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Once started, ART suppressed HIV and SARS-CoV-2 cleared within nine weeks.<\/span><\/p>\n<div>\n<p class=\"HTBcommenttitle\" align=\"left\"><span lang=\"EN-US\">The 22-year-old South African has been HIV positive since birth. At time of presentation her HIV was not well managed with viral load &gt;100,000 copies\/mL and CD4 count of 91 cells\/mm<sup>3<\/sup>. Restarting ART reduced viral load but 8 months later, viremia remained high and COVID-19 illness persisted. Switching to a TLD regimen reduced viral load to \u226550 copies\/mL and COVID-19 cleared within 6 to 9 weeks. <\/span><\/p>\n<\/div>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Ref: Maponga TG et al. Persistent SARS-CoV-2 infection with accumulation of mutations in a patient with poorly controlled HIV infection. Clinical Infectious Diseases, ciac548,\u00a0doi: 10.1093\/cid\/ciac548 (06 July 2022).<br \/>\n<\/span><a href=\"https:\/\/academic.oup.com\/cid\/advance-article\/doi\/10.1093\/cid\/ciac548\/6632801\">https:\/\/academic.oup.com\/cid\/advance-article\/doi\/10.1093\/cid\/ciac548\/6632801<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Kirk Taylor, HIV i-Base This paper includes a case report that tracks the accumulation of more than 20 key mutations in an HIV positive person with prolonged COVID-19. Once started, ART suppressed HIV and SARS-CoV-2 cleared within nine weeks. The &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[31,278],"tags":[],"class_list":["post-43648","post","type-post","status-publish","format-standard","hentry","category-opportunistic-infections-coinfections-and-complications","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/43648","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=43648"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/43648\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=43648"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=43648"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=43648"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}