{"id":43758,"date":"2022-09-01T06:27:18","date_gmt":"2022-09-01T06:27:18","guid":{"rendered":"https:\/\/127.0.0.1\/htb\/?p=43758"},"modified":"2022-09-23T14:19:33","modified_gmt":"2022-09-23T14:19:33","slug":"tecovirimat-for-treating-mild-monkeypox-platinum-study-opens-in-the-uk","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/43758","title":{"rendered":"Tecovirimat for treating mild monkeypox: new studies open in the UK and US"},"content":{"rendered":"

Simon Collins, HIV i-Base<\/strong><\/p>\n

\"\"<\/strong>On 23 August 2022, the PLATIMUM study was launched in the UK to look at using tecovirimat to treat monkeypox (MPX). [1]<\/b><\/p>\n

This study plans to randomise 500 people (1:1) with mild MPX to either tecovirimat or matching placebo. Follow-up is for 28 days.<\/p>\n

Participants need a referral from their doctor, but no further clinic visits are needed. This means that anyone who is self-isolating can still take part. The referral email is simple and only takes a few minutes (www.platinumtrial.ox.ac.uk\/healthcare-workers2<\/a>).<\/p>\n

Although tecovirimat interacts with some HIV medications (darunavir, rilpivirine and maraviroc) these are either not cliniclly important or can be easily managed.<\/p>\n

Other drugs with potential interactions include: bupropion. repaglinide, voriconazole, midazolam, atorvastatin, tacrolimus, methadone, flurbiprofen, erectile drugs\u00a0(sildenafil, tadalafil, vardenafil) and proton pump inhibitors (lansoprazole, omeprazole, rabeprazole).<\/p>\n

Anyone with severe MPX, especially if hospitalised, should have named-patient access to tecovirimat without needing to join a placebo-controlled study.<\/p>\n

Further participant information and the study protocol are available online.<\/p>\n

In the US, the phase 3 STOMP study is randomising 530 adults and children with MPX (2:1) to either tecovirimat or placebo. It asks people to send photographs of their symptoms as part of the ongoing monitoring. [2, 3]<\/p>\n

comment<\/b><\/h3>\n

Several studies have already reported anecdotal evidence on potential benefits of tecovirimat to treat MPX, also supported in animal studies for smallpox. [4, 5, 6, 7, 8, 9]<\/b><\/p>\n

This includes, as we went to press, a review of open-label use of tecovirimat in 549 participants in the US, reported in MMWR. Data is included for about 350 people. [9]<\/strong><\/p>\n

This makes results from a randomised study essential in order to be able to inform future access and use. This is a very study to refer people to \u2013 only a standard email \u2013 but the referral is needed.<\/b><\/p>\n

Results should similarly be compiled from open-label use, although these will be more limited.<\/b><\/p>\n

The PLATINUM study is also linked to a similar study in Canada. [10]<\/strong><\/p>\n

References<\/p>\n

    \n
  1. The PLATINUM study website.
    \n    platinumtrial.ox.ac.uk<\/a><\/li>\n
  2. Study of Tecovirimat for Human Monkeypox Virus (STOMP)?
    \n    www.stomptpoxx.org<\/a><\/li>\n
  3. A5418:Study Of Tecovirimat For Human Monkeypox Virus (STOMP)
    \n    clinicaltrials.gov\/ct2\/show\/NCT05534984<\/a><\/li>\n
  4. Seven cases of monkeypox virus in the UK from 2018 to 2021. HTB (1 June 2022).
    \n    i-base.info\/htb\/42959<\/a><\/li>\n
  5. Desai AN et al. Compassionate use of tecovirimat for the treatment of monkeypox infection. JAMA. doi:10.1001\/jama.2022.15336. (22 August
    \n2022).
    \n    jamanetwork.com\/journals\/jama\/fullarticle\/2795743<\/a><\/li>\n
  6. Thornhill JP et al for the SHARE-net clinical group. Monkeypox virus infection in humans across 16 countries \u2014 April\u2013June 2022. NEJM, doi: DOI:
    \n1056\/NEJMoa2207323. (21 July 2022).
    \n    www.nejm.org\/doi\/full\/10.1056\/NEJMoa2207323<\/a><\/li>\n
  7. Lucer J et al. Monkeypox virus\u2013associated severe proctitis treated with oral tecovirimat: a report of two cases. Letter. Annals Internal Medicine. doi.org\/10.7326\/L22-0300. (18 August 2022).
    \n    www.acpjournals.org\/doi\/10.7326\/L22-0300<\/a><\/li>\n
  8. Grosenbach DW et al. Oral tecovirimat for the treatment of smallpox. N Engl J Med 2018;379:44-53.
    \n    www.nejm.org\/doi\/full\/10.1056\/NEJMoa1705688<\/a><\/li>\n
  9. O\u2019Laughlin K et al. Clinical use of tecovirimat (Tpoxx) for treatment of monkeypox under an investigational new drug protocol \u2014 United States, May\u2013August 2022. MMWR Morb Mortal Wkly Rep. ePub: 9 September 2022. DOI: http:\/\/dx.doi.org\/10.15585\/mmwr.mm7137e1<\/a><\/li>\n
  10. ClinicalTrials.org. Tecovirimat in non-hospitalized patients with monkeypox. (PLATINUM-CAN).
    \n    clinicaltrials.gov\/ct2\/show\/NCT05534165<\/a><\/li>\n<\/ol>\n

    This page was updated on 11 September to includ US and Canadian studies.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

    Simon Collins, HIV i-Base On 23 August 2022, the PLATIMUM study was launched in the UK to look at using tecovirimat to treat monkeypox (MPX). [1] This study plans to randomise 500 people (1:1) with mild MPX to either tecovirimat …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[323],"tags":[],"class_list":["post-43758","post","type-post","status-publish","format-standard","hentry","category-mpox"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/43758","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=43758"}],"version-history":[{"count":17,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/43758\/revisions"}],"predecessor-version":[{"id":44115,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/43758\/revisions\/44115"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=43758"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=43758"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=43758"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}