{"id":44141,"date":"2022-10-03T07:45:19","date_gmt":"2022-10-03T07:45:19","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=44141"},"modified":"2022-11-12T20:11:01","modified_gmt":"2022-11-12T20:11:01","slug":"switch-study-for-people-with-insomnia-using-dolutegravir-2","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/44141","title":{"rendered":"Switch study for people with insomnia using dolutegravir: still enrolling"},"content":{"rendered":"<p><strong>St Mary&#8217;s London and Royal Sussex Brighton<\/strong><\/p>\n<p><strong>A new study being run in London and Brighton is looking to recruit 46 adults who are experiencing sleep problems using dolutegravir-based ART. [1]<\/strong><\/p>\n<p>The study will look at whether switching ART from dolutegravir + 2NRTIs to Biktarvy (tenofovir-AF\/emtricitabine\/bictegravir) is associated with improved sleep.<\/p>\n<p>Half the participants will switch and half will continue on their current treatment.<\/p>\n<p>The study will look at brain function using two functional MRI brain imaging scans. It will also include participant questionnaires, including on\u00a0 sleep quality.<\/p>\n<p>The study involves six routine clinic visits over five months and two scanning visits.<\/p>\n<p>It is running at St. Mary\u2019s Hospital in London and Brighton and Royal Sussex County Hospital in Brighton. It is funded by Gilead Sciences.\u00a0HIV positive people are able to self-refer if interested.<em>\u00a0<\/em><\/p>\n<p>Please email the study team if you would like more information or if you are interested in joining.<br \/>\n<a href=\"mailto:imperial.ctc@nhs.net\">imperial.ctc@nhs.net<\/a><\/p>\n<p>Further details are also online. [1]<\/p>\n<p>Reference<\/p>\n<p>Bictegravir central nervous system (CNS) study. ICRCTN register 17508886.<br \/>\n<a href=\"https:\/\/www.isrctn.com\/ISRCTN17508886\">https:\/\/www.isrctn.com\/ISRCTN17508886<\/a><\/p>\n<p><em>This report was first published on 8 October 2021.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>St Mary&#8217;s London and Royal Sussex Brighton A new study being run in London and Brighton is looking to recruit 46 adults who are experiencing sleep problems using dolutegravir-based ART. [1] The study will look at whether switching ART from &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[189],"tags":[],"class_list":["post-44141","post","type-post","status-publish","format-standard","hentry","category-research-studies"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/44141","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=44141"}],"version-history":[{"count":3,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/44141\/revisions"}],"predecessor-version":[{"id":44383,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/44141\/revisions\/44383"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=44141"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=44141"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=44141"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}