{"id":4451,"date":"2009-08-23T10:47:35","date_gmt":"2009-08-23T10:47:35","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=4451"},"modified":"2013-08-16T13:11:24","modified_gmt":"2013-08-16T13:11:24","slug":"four-weeks-lopinavirr-to-cover-functional-monotherapy-when-stopping-haart","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/4451","title":{"rendered":"Four weeks lopinavir\/r to cover functional monotherapy when stopping HAART"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p><strong>Taylor and colleagues from Birmingham Heartlands Hospital presented results from a pilot study that switched 20 patients to four weeks lopinavir\/r monotherapy on day 0 of a planned treatment interruption.<\/strong> [1]<\/p>\n<p>This protective strategy was designed to reduce the risk of resistance while drug levels dropped, as many regimens combine individual drugs with different plasma and intracellular half-lives, and is complicated in the case of NNRTIs by genetic polymorphisms related to higher exposure and slower clearance. This strategy was previously discussed in a paper in AIDS as probably the safest way to stop treatment. [2]<\/p>\n<p>Twelve of the regimens in this study were judged likely to risk functional monotherapy: 8 for NNRTIs and 4 for tenofovir or FTC.<\/p>\n<p>Viral suppression was maintained in most patients, thoughout the period of monotherapy (14\/17 with results), and three patients with detectable viral load at baseline experienced significant viral declines on lopinavir\/r.<\/p>\n<p>Lopinavir levels remained above the minimum target of 1000ng\/mL, except in two patients with suspected non-adherence and viral load rebounded by week 8 in all 12 patients who discontinued lopinavir\/r at week 4.<\/p>\n<p>The importance of this approach was highlighed by 6\/12 patients on \u0091unbalanced\u0092 regimens having residual drug concentrations of their initial ARVs more than one week after stopping those combinations.<\/p>\n<p>References:<\/p>\n<ol>\n<li>Taylor S et al. Kaletra single agent therapy as a universal ART stopping strategy: the STOP 2 study. 10th International Workshop on Clinical Pharmacology of HIV Therapy, 15-17 April 2009, Amsterdam. Poster abstract P-17.<\/li>\n<li>Taylor S, Boffito M, Khoo S, Smit E, Back D. Stopping antiretroviral therapy. AIDS 2007; 21:1673-1682. (20 August 2007). doi: 10.1097\/QAD.0b013e3281c61394.<br \/>\n<a href=\"http:\/\/journals.lww.com\/aidsonline\/Fulltext\/2007\/08200\/Stopping_antiretroviral_therapy.1.aspx\">http:\/\/journals.lww.com\/aidsonline\/Fulltext\/2007\/0820 0\/Stopping_antiretroviral_therapy.1.aspx<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base Taylor and colleagues from Birmingham Heartlands Hospital presented results from a pilot study that switched 20 patients to four weeks lopinavir\/r monotherapy on day 0 of a planned treatment interruption. [1] This protective strategy was designed &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,3],"tags":[133],"class_list":["post-4451","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-antiretrovirals","tag-pk-workshop-10th-2009"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4451","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=4451"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4451\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=4451"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=4451"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=4451"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}