{"id":44785,"date":"2023-02-01T08:00:03","date_gmt":"2023-02-01T08:00:03","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=44785"},"modified":"2024-07-10T12:36:59","modified_gmt":"2024-07-10T12:36:59","slug":"htb-january-february-2023-1-february-2023","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/44785","title":{"rendered":"HTB January\/February 2023 (1 February 2023)"},"content":{"rendered":"<ul>\n<li><a href=\"https:\/\/i-base.info\/htb\/date\/2023\/02\">Contents online<\/a><\/li>\n<li><a href=\"https:\/\/i-base.info\/htb\/wp-content\/uploads\/2023\/07\/HIV-1-2-JanFeb-.pdf\" rel=\"noopener\">Download HIV no 1\/2 &#8211;\u00a0PDF<\/a><\/li>\n<li><a href=\"https:\/\/i-base.info\/forms\/esub.php\">Subscribe to HTB by email<\/a><\/li>\n<\/ul>\n<div>\n<p class=\"HTBBODYtext\"><strong><span lang=\"EN-US\"><a href=\"https:\/\/i-base.info\/wp-content\/uploads\/2023\/02\/HIV-1-2-JanFeb-COVER.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-17095 alignright\" src=\"https:\/\/i-base.info\/wp-content\/uploads\/2023\/02\/HIV-1-2-JanFeb-COVER-711x1024.png\" alt=\"\" width=\"200\" height=\"283\" \/><\/a>Welcome to the first issue of HTB for 2023.<\/span><\/strong><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Optimistically, we look forward to the upcoming 30th CROI conference. The preliminary programme is now online and we suggest a few conference highlights &#8211; and during the meeting we will post early reports, linked to the same page.<\/span><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">We also include the final reports from the Glasgow conference, covering recent and pipeline ART.<\/span><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">The rest of this issue includes a range of journal reports that haven&#8217;t generated widespread media coverage but that are nonetheless significant and important:<\/span><\/p>\n<\/div>\n<div>\n<ul>\n<li class=\"HTBBODYtext\"><span lang=\"EN-US\">That there were zero transmissions to infants when the mother was on effective ART at conception, during pregnancy and at birth. This was in a large French cohort with good access to ART.<\/span><\/li>\n<li class=\"HTBBODYtext\">Additional evidence to support recycling modern NRTIs in second-line ART, even with evidence of drug resistance.<\/li>\n<li class=\"HTBBODYtext\">That unexpected viral rebound and persistent low-level viraemia on previously effective ART may be due to clonal expansion rather than viral failure related to poor adherence and\/or drug resistance. This phenomenon might affect 1 in 250 people on ART and is not currently covered in treatment guidelines,<\/li>\n<li class=\"HTBBODYtext\">That integrase inhibitors as a class might have greater impact on recovery of CD4:CD8 ratio than either NNRTI- or PI-based ART.<\/li>\n<li class=\"HTBBODYtext\">That HIV reinfection might be as common as 7%.<\/li>\n<li><span lang=\"EN-US\">That the Mosaico HIV vaccine study which was discontinued in January due to HIV infection rates of<i> <\/i>4.1\/100 person-years of follow-up in both the active and placebo arms.<\/span><\/li>\n<li>A short report on the risk of KS in people on effective ART.<\/li>\n<li>BOTOX as a potential treatment for erectile dysfunction.<\/li>\n<\/ul>\n<\/div>\n<div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">We also approach the first anniversary of the war against Ukraine that most of us either feared or hoped might be over in months, at a time when Western governments are supplying military aid that might have helped an earlier outcome had it been provided earlier.<\/span><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">HTB still leads with information about ways to help, including donating unused medicines.<\/span><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>CROI 2023 and Glasgow 2022 + latest journal reviews&#8230;<\/p>\n","protected":false},"author":3,"featured_media":44804,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-44785","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-editorial"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/44785","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=44785"}],"version-history":[{"count":14,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/44785\/revisions"}],"predecessor-version":[{"id":45755,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/44785\/revisions\/45755"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media\/44804"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=44785"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=44785"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=44785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}