{"id":44950,"date":"2023-03-10T07:38:57","date_gmt":"2023-03-10T07:38:57","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=44950"},"modified":"2023-04-10T19:38:21","modified_gmt":"2023-04-10T19:38:21","slug":"efficacy-of-n6ls-monotherapy-correlated-with-baseline-factors","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/44950","title":{"rendered":"CROI 2023: Efficacy of N6LS monotherapy correlated with baseline factors"},"content":{"rendered":"
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Kirk Taylor, HIV i-Base<\/span><\/strong><\/p>\n<\/div>\n

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\"\"<\/strong>CROI 2023 included a study of baseline factors influencing maximum viral decrease and time to viral rebound for treatment naive participants receiving the N6LS (VH38101019) bNAb. [1] <\/span><\/p>\n<\/div>\n

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A modest correlation was observed between baseline IC80 and CD4 count and the magnitude of virologic response. <\/span><\/p>\n<\/div>\n

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Treatment-naive people living with HIV were randomised to receive either 40 mg\/kg (n=8) or 4 mg\/kg (n=6) infusion of N6LS as monotherapy. Participants were male (n=13), white (n=11) and Latinx (n=10). Baseline viral load was 4.31 log copies\/mL (range: 3.13 to 5.24) and median CD4 count was 369 cells\/mm3<\/sup> (range: 190 to 700). <\/span><\/p>\n<\/div>\n

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Virologic response was observed for all participants. Median viral decrease was \u20131.72 log copies\/mL (range: \u20132.60 to \u20130.60) and \u20131.18 log copies\/mL (range: \u20132.18 to \u20130.30) for the 40 mg\/kg and 4mg\/kg groups, respectively. <\/span><\/p>\n<\/div>\n

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For the 40 mg\/kg group, median time to viral nadir was 16 days (range: 5 to 16 days) and rebound occurred after 35 days (range: 12 to 78 days). Participants in the 4 mg\/kg responded faster with a median time to nadir of 9 days (range: 7 to 16 days), but time to viral rebound was also faster (median: 18 days, range: 14 to 29 days). <\/span><\/p>\n<\/div>\n

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Baseline IC80 and CD4 count modestly correlated with the maximum decline of viral load and the time to viral rebound. A weak correlation was also observed between lower baseline viral load and increased virologic response. <\/span><\/p>\n<\/div>\n

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Adverse events were reported by 9 participants and all drug- and ISR-related AEs were grade 1. Alternative dosing options are being evaluated in BANNER part 2.<\/span><\/p>\n<\/div>\n

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Reference<\/span><\/p>\n<\/div>\n

Leone P et al. Impact of baseline factors on virologic response to bNAb VH381010109 (N6LS) in BANNER. 30th Conference on Retroviruses and Opportunistic Infections, 19 \u2013 22 February 2023, Seattle and hybrid. Poster Abstract 520.<\/div>\n
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https:\/\/www.croiconference.org\/abstract\/impact-of-baseline-factors-on-virologic-response-to-bnab-vh3810109-n6ls-in-banner\/<\/a> (abstract)<\/p>\n

This report was first published on 2 March 2023.<\/em><\/p>\n<\/div>\n

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\u00a0<\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Kirk Taylor, HIV i-Base CROI 2023 included a study of baseline factors influencing maximum viral decrease and time to viral rebound for treatment naive participants receiving the N6LS (VH38101019) bNAb. [1] A modest correlation was observed between baseline IC80 and …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,3],"tags":[327],"class_list":["post-44950","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-antiretrovirals","tag-croi-2023"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/44950","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=44950"}],"version-history":[{"count":8,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/44950\/revisions"}],"predecessor-version":[{"id":45133,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/44950\/revisions\/45133"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=44950"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=44950"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=44950"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}