{"id":44981,"date":"2023-03-10T07:30:04","date_gmt":"2023-03-10T07:30:04","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=44981"},"modified":"2023-04-10T19:42:13","modified_gmt":"2023-04-10T19:42:13","slug":"improved-bone-density-profile-for-cab-la-vs-oral-prep","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/44981","title":{"rendered":"CROI 2023: Bone density profiles for CAB-LA vs TDF\/FTC oral PrEP in young adults"},"content":{"rendered":"
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Kirk Taylor, HIV i-Base<\/strong><\/p>\n<\/div>\n

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\"\"<\/span><\/strong>TDF\/FTC oral PrEP is associated with BMD loss but the impact of CAB-LA on BMD is unknown. CROI 2023 included a BMD study that demonstrated median increased BMD percentage from baseline (from +0.5 to +1.5%) for participants who received CAB-LA PrEP. [1]<\/p>\n<\/div>\n

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A bone sub-study of HPTN-083 was conducted at 19 sites and included people taking oral (TDF\/FTC, n=122) or CAB-LA (n=132) PrEP. Low BMD (Z-score \u22642.0) at baseline was observed for 15% (oral) and 16% (LA) of participants. The study measured BMD at lumbar spine, femoral neck and hip.<\/p>\n<\/div>\n

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At week 105, participants in the oral group saw a median percentage decline in BMD across the three sites of \u20130.5 to \u20131%. Conversely, median BMD increased by +0.5 to +1.5% for participants receiving CAB-LA. These findings suggest that those at risk of osteoporosis or fracture may be better suited to CAB-LA PrEP.<\/p>\n<\/div>\n

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This sub-study recruited gay men (90%) and trans women (10%) and other baseline demographics included: white (47%), Black (31%) and Asian (12%). Median age was 29 years (IQR: 23 to 41) for oral and 26 years (IQR: 22 to 31 years) for CAB-LA PrEP formulations. 8% of the study population were \u226550 years old.<\/p>\n

comment<\/h3>\n

These results are not unexpected although it is unclear whether the overall differences at week 105 are statistically significant given the lower age at baseline in the CAB-LA arm, when bones are still growing.<\/strong><\/p>\n<\/div>\n

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Reference<\/p>\n<\/div>\n

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Brown TT et al. Bone density changes with CAB-LA or TDF\/FTC PrEP in MSM and TGW in HPTN 083. 30th CROI, 19\u201322 February 2023, 30th Conference on Retroviruses and Opportunistic Infections, 19 \u2013 22 February 2023, Seattle and hybrid . Poster Presentation 987.
\nhttps:\/\/www.croiconference.org\/abstract\/bone-density-changes-with-cab-la-or-tdf-ftc-prep-in-msm-and-tgw-in-hptn-083\/ (abstract)<\/a><\/p>\n

This report was first published on 9 March 2023.<\/em><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Kirk Taylor, HIV i-Base TDF\/FTC oral PrEP is associated with BMD loss but the impact of CAB-LA on BMD is unknown. CROI 2023 included a BMD study that demonstrated median increased BMD percentage from baseline (from +0.5 to +1.5%) for …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,8,10],"tags":[],"class_list":["post-44981","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-side-effects","category-transmission-and-prevention"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/44981","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=44981"}],"version-history":[{"count":13,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/44981\/revisions"}],"predecessor-version":[{"id":45280,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/44981\/revisions\/45280"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=44981"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=44981"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=44981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}