{"id":45024,"date":"2023-03-10T07:37:01","date_gmt":"2023-03-10T07:37:01","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=45024"},"modified":"2023-04-09T13:39:28","modified_gmt":"2023-04-09T13:39:28","slug":"cab-rpv-la-levels-are-not-reduced-after-switching-from-efavirenz","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/45024","title":{"rendered":"CROI 2023: CAB\/RPV-LA levels are not reduced after switching from efavirenz"},"content":{"rendered":"<div>\n<p class=\"HTBsubhead3authorcredit\"><strong>Kirk Taylor, HIV i-Base<\/strong><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><strong><span lang=\"EN-US\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-44826 alignright\" src=\"https:\/\/i-base.info\/htb\/wp-content\/uploads\/2023\/02\/CROI-2023-logo-222x300.png\" alt=\"\" width=\"191\" height=\"255\" \/><\/span>Because efavirenz (EFV) induces UGT1A1\/CYP3A4 and this might lead to early clearance of CAB\/RPV-LA, researchers modelled this potential interaction using an in-house PKPB model. Results presented at CROI 2023 suggests that this is not a concern. [1]<\/strong><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\">A cohort of 100 people was modelled to simulate the impact of EFV on CAB\/RPV levels. All predicted values were within a 2-fold range of clinical data. Initiation of LA-CAB\/RPV 12 hours after the final EFV dose only had a small effect on Cmin values.<\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\">CAB and RPV Cmin were \u226587% of the expected value. This effect was transient and Cmin at day-28 was 98% of control.<\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\">Reference<\/p>\n<\/div>\n<div>\n<p class=\"HTBreferences\"><span lang=\"EN-US\">Bettonte S. Intramuscular cabotegravir\/rilpivirine concentrations after switching from efavirenz.<\/span><span lang=\"EN-US\"> 30th Conference on Retroviruses and Opportunistic Infections, 19 \u2013 22 February 2023, Seattle and hybrid. Poster Abstract 508.<br \/>\n<\/span><a href=\"https:\/\/www.croiconference.org\/abstract\/intramuscular-cabotegravir-rilpivirine-concentrations-after-switching-from-efavirenz\/\"><span lang=\"EN-US\">https:\/\/www.croiconference.org\/abstract\/intramuscular-cabotegravir-rilpivirine-concentrations-after-switching-from-efavirenz\/<\/span><\/a><\/p>\n<p>&lt;\/div<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Kirk Taylor, HIV i-Base Because efavirenz (EFV) induces UGT1A1\/CYP3A4 and this might lead to early clearance of CAB\/RPV-LA, researchers modelled this potential interaction using an in-house PKPB model. Results presented at CROI 2023 suggests that this is not a concern. &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,34],"tags":[327],"class_list":["post-45024","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-pk-and-drug-interactions","tag-croi-2023"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/45024","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=45024"}],"version-history":[{"count":9,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/45024\/revisions"}],"predecessor-version":[{"id":45241,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/45024\/revisions\/45241"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=45024"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=45024"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=45024"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}