{"id":4568,"date":"2001-06-30T13:32:44","date_gmt":"2001-06-30T12:32:44","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=4568"},"modified":"2014-06-12T13:27:16","modified_gmt":"2014-06-12T13:27:16","slug":"more-than-one-way-to-skin-a-virus-innate-immune-factors-that-suppress-hiv-replication","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/4568","title":{"rendered":"Keystone Symposium on HIV, March 28-April 3, Keystone, Colorado: more than one way to skin a virus: innate immune factors that suppress HIV replication"},"content":{"rendered":"<p><strong>by Jo Ann Berg<\/strong><\/p>\n<p><strong>Report from Keystone, March 2001<\/strong><\/p>\n<p>This year&#8217;s annual Keystone Symposium on HIV, held March 28 to April 3 in Keystone, Colorado, featured concurrent sessions on &#8220;AIDS Vaccines in the New Millennium&#8221; and &#8220;HIV Pathogenesis&#8221; (how the microbe causes disease).<\/p>\n<p>Previous meetings on pathogenesis have emphasized the adaptive immune response: antibodies and CD8+ cytotoxic T lymphocytes (CTLs). The antibodies are specifically shaped to attach to and help eliminate free HIV particles in the body while the CTLs are specially selected and activated to kill HIV-infected cells. Antibodies to HIV have generally proven ineffective, and the CTL response wanes as HIV infection progresses. AIDS scientists are taking a renewed interest in the body&#8217;s first line of defence &#8211; the nonspecific, or innate, immune system. Fifteen years ago, Jay Levy&#8217;s laboratory at the University of California San Francisco observed that certain CD8+ T-cells active during HIV infection do not kill HIV-infected cells.1 They instead release a soluble factor or factors that render nearby CD4+ T-helper cells resistant to destruction by HIV.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>by Jo Ann Berg Report from Keystone, March 2001 This year&#8217;s annual Keystone Symposium on HIV, held March 28 to April 3 in Keystone, Colorado, featured concurrent sessions on &#8220;AIDS Vaccines in the New Millennium&#8221; and &#8220;HIV Pathogenesis&#8221; (how the &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[12],"class_list":["post-4568","post","type-post","status-publish","format-standard","hentry","category-conference-reports","tag-conference-index"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4568","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=4568"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4568\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=4568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=4568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=4568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}