{"id":45912,"date":"2023-08-01T07:33:50","date_gmt":"2023-08-01T07:33:50","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=45912"},"modified":"2023-08-04T16:22:02","modified_gmt":"2023-08-04T16:22:02","slug":"high-rates-of-occult-hbv-in-botswana-that-would-be-missed-by-hbsag-screening","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/45912","title":{"rendered":"High rates of occult HBV in Botswana: risks from relying on HBsAg screening"},"content":{"rendered":"
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Simon Collins, HIV i-Base<\/strong><\/p>\n<\/div>\n

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Although screening for hepatitis B often relies on testing for HBsAg, a poster at IAS 2023 with data from two longitudinal HIV studies in Botswana reported high rates of occult HBV infection (OBI) that can still cause liver disease and be transmissible.<\/span><\/strong><\/p>\n<\/div>\n

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This highlights an advantage from using triple therapy ART that is active against both HIV and HBV.<\/span><\/p>\n<\/div>\n

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The study tested for HBsAg using ELISA and negative samples were screened for OBI using an in-house real-time PCR.<\/span><\/p>\n<\/div>\n

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Baseline prevalence of HBsAg and OBI was 2.1% (8\/382) and 14.7% (11\/75), respectively.<\/span><\/p>\n<\/div>\n

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During a median of 1.02 years follow-up (IQR: 1.00 to 2.00) in 90 participants, there were 34 incident OBI cases, with an IR of 26.4\/100 person-years (95% CI: 18.9 to 36.9). The median time to incident OBI was 372 days (IQR: 365 to 730).\u00a0<\/span><\/p>\n<\/div>\n

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Reference<\/span><\/p>\n<\/div>\n

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Anderson M et al. Incidence of occult hepatitis B virus among people living with HIV in Botswana, IAS 2023. poster abstract EPB0158.
\n<\/span>https:\/\/programme.ias2023.org\/Abstract\/Abstract\/?abstractid=4926<\/span><\/a> (abstract)
\n<\/span>https:\/\/conference.ias2023.org\/media-1007-incidence-of-occult-hepatitis-b-virus-among-people-living-with-hiv-in-botswana<\/a> (poster)<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Simon Collins, HIV i-Base Although screening for hepatitis B often relies on testing for HBsAg, a poster at IAS 2023 with data from two longitudinal HIV studies in Botswana reported high rates of occult HBV infection (OBI) that can still …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,24],"tags":[329],"class_list":["post-45912","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-hepatitis-coinfection","tag-ias-2023"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/45912","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=45912"}],"version-history":[{"count":12,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/45912\/revisions"}],"predecessor-version":[{"id":45931,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/45912\/revisions\/45931"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=45912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=45912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=45912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}