{"id":46282,"date":"2023-10-01T07:20:57","date_gmt":"2023-10-01T07:20:57","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=46282"},"modified":"2023-10-03T23:46:12","modified_gmt":"2023-10-03T23:46:12","slug":"altered-kidney-function-associated-with-alcohol-and-cannabis-use-by-women-living-with-hiv","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/46282","title":{"rendered":"Altered kidney function associated with alcohol and cannabis use by women living with HIV"},"content":{"rendered":"<p><strong>Kirk Taylor, HIV i-Base<\/strong><\/p>\n<p><strong>The June issue of AIDS included a prospective cohort study of the effect of substance use (e.g. alcohol and cannabis) on kidney function for women living with or without HIV.<\/strong><\/p>\n<p>Participants were recruited from a US multicentre prospective cohort study and were living with (n=1043) or without (n=469) HIV. Median age was higher for people with HIV compared to HIV negative participants: 46 years (IQR: 41 to 52) vs 42 years (IQR: 35 to 50). People living with HIV had CD4 counts \u2265200 cells\/mm<sup>3<\/sup>\u00a0 (86%), undetectable viral load (54%) and art regimens included TDF (60%).<\/p>\n<p>Substance use data was collected bi-annually and eGFR (estimated glomerular filtration rate) was calculated across a decade (2009 to 2019). Linear regression analyses were adjusted for HIV factors and kidney disease to identify associations between substance use and kidney function.<\/p>\n<p>Using cannabis for up to 14 days per month decreased eGFR by 3.34 mL\/min per 1.73m<sup>2<\/sup> (95% CI: -6.63 to -0.06 ml\/min per 1.73m<sup>2<\/sup>), compared to those that did not report cannabis use.<\/p>\n<p>Having \u22657 alcoholic drinks per week increased eGFR by 5.41 ml\/min per 1.73m<sup>2<\/sup> (95% CI: 2.34 to 8.48 ml\/min per 1.73m<sup>2<\/sup>), relative to non-drinkers.<\/p>\n<p>There was no association between tobacco use and eGFR. The study did not report any differences between women living with HIV and those that were HIV negative.<\/p>\n<p>Reference<\/p>\n<p>Fisher MC et al. Association of marijuana, tobacco and alcohol use with estimated glomerular filtration rate in women living with HIV and women without HIV. AIDS 37(10), 1555-1564. DOI: 10.1097\/QAD.0000000000003625 (09 June 2023).<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37352493\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37352493\/<\/a><\/p>\n<p><em>This report was first posted on 13 September 2023.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kirk Taylor, HIV i-Base The June issue of AIDS included a prospective cohort study of the effect of substance use (e.g. alcohol and cannabis) on kidney function for women living with or without HIV. Participants were recruited from a US &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-46282","post","type-post","status-publish","format-standard","hentry","category-side-effects"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/46282","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=46282"}],"version-history":[{"count":8,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/46282\/revisions"}],"predecessor-version":[{"id":46414,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/46282\/revisions\/46414"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=46282"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=46282"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=46282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}