{"id":46801,"date":"2023-12-01T07:37:59","date_gmt":"2023-12-01T07:37:59","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=46801"},"modified":"2023-12-21T09:24:01","modified_gmt":"2023-12-21T09:24:01","slug":"prevalence-of-doravirine-drug-resistance-in-large-cohort-in-british-columbia","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/46801","title":{"rendered":"EACS 2023: Prevalence of doravirine drug resistance in large cohort in British Columbia"},"content":{"rendered":"

Kirk Taylor, HIV i-Base<\/strong><\/p>\n

>\"\"EACS 2023 included an oral presentation on the prevalence of mutations associated with resistance to doravirine in a large observational cohort in British Columbia.<\/strong><\/p>\n

A database reviewed almost 39,000 sequences collected since 1996 from more than 10,000 people living with HIV at the BC Centre for Excellence in HIV\/AIDS.<\/p>\n

Approximately 5400 samples were NNRTI-naive, 15,400 were NNRTI-experienced and 18,000 with an unknown NNRTI history were assumed to have started with PI- or INSTI-based ART (but not commenting on whether this was linked to baseline resistance).<\/p>\n

Doravirine resistance was categorised based on having one or more primary or secondary major mutations or having at least 5 minor mutations (based on Stanford).<\/p>\n\n\n\n\n\n
Primary major<\/td>\nY106A, Y188L, F227C\/V, M230I\/L, L234I, Y318F<\/td>\n<\/tr>\n
Secondary major<\/td>\nA98G, V106M, V108L, G190E, H221Y, P225H, F227L, P236L<\/td>\n<\/tr>\n
Minor mutations<\/td>\nV90I, K101E\/H\/P, K103N\/R\/, V106L, I135T, Y181C\/I\/V, E138A\/G\/K\/Q\/R, V179D\/F\/T, G109A\/Q\/S, Y188C\/H, F2271, V245E, K311R<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Overall, 20% genotypes (7995\/38,808) included any NNRTI resistance (including 30% of those who were NNRTI-experienced). Only 835 samples (2.2%) showed resistance to doravirine (roughly 5% of those who were NNRTI-experienced.<\/p>\n

Of the 230 people prescribed doravirine, 32% (75\/230) had previous NNRTI resistance but most switched when already undetectable and used either triple-class or four-drug combinations, with only 10\/75 starting on doravirine plus two NRTIs.<\/p>\n

The three people with virological failure had single mutations at (i) V106M, (ii) M230L and (iii) with multiple mutations at V106I\/M+V108I+F227C+M230L+L234I.<\/p>\n

Reference:<\/p>\n

Brumme C. Prevalence and clinical impact of doravirine-associated resistance mutations in a real-world population of NNRTI-na\u00efve and NNRTI-experienced individuals. 19th EACS, 18\u201321 October 2023, Warsaw, Poland.. Oral Presentation PS 1.05.
\nhttps:\/\/eacs2023.abstractserver.com\/program\/#\/details\/presentations\/546<\/a> (abstract)
\nhttps:\/\/live.allintheloop.net\/Agenda\/EACS\/EACS2023\/greenLiveStream\/444748\/2<\/a> (webcast with login)<\/p>\n","protected":false},"excerpt":{"rendered":"

Kirk Taylor, HIV i-Base >EACS 2023 included an oral presentation on the prevalence of mutations associated with resistance to doravirine in a large observational cohort in British Columbia. A database reviewed almost 39,000 sequences collected since 1996 from more than …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,189],"tags":[330],"class_list":["post-46801","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-research-studies","tag-eacs-19-2023"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/46801","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=46801"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/46801\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=46801"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=46801"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=46801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}