{"id":46957,"date":"2023-12-01T07:11:58","date_gmt":"2023-12-01T07:11:58","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=46957"},"modified":"2023-12-15T18:37:12","modified_gmt":"2023-12-15T18:37:12","slug":"pricing-new-gene-therapies-for-sickle-cell-implications-for-an-hiv-cure","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/46957","title":{"rendered":"Pricing new gene therapies for sickle-cell: implications for an HIV cure"},"content":{"rendered":"<p><b>Simon Collins, HIV i-Base<\/b><\/p>\n<p><b>The recent UK and US approvals for gene therapy approaches to treat and potentially cure sickle-cell disease are remarkable scientific advances. [1, 2]<\/b><\/p>\n<p>They also come with prices of upwards of $2 million for a single treatment.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>The model supporting this cavalier approach to pricing is based on reducing the lifetime costs of treating sickle-cell disease.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>A similar model for hepatitis C drugs, justified the $1000 a pill price by including the costs of a liver transplant. It is also disassociated from both the research and manufacturing costs. Generic formulations for these meds are now produced at a fraction of these prices.<\/p>\n<p>The model is also based on the US only treating 2000 people per year, although more than 100,000 people in the US are likely to have sickle-cell disease, which predominently affects Black communities.<\/p>\n<p>We include this news in HTB because gene therapy is one of the most active approaches to finding a cure for HIV. If this research is scientifically successful, we will have the same issues of cost in order to achieve access by those who need it most.<\/p>\n<p>References<\/p>\n<ol>\n<li>MHRA press release. MHRA authorises world-first gene therapy that aims to cure sickle-cell disease and transfusion-dependent \u03b2-thalassemia. (16 November 2023).<br \/>\n<a href=\"https:\/\/www.gov.uk\/government\/news\/mhra-authorises-world-first-gene-therapy-that-aims-to-cure-sickle-cell-disease-and-transfusion-dependent-thalassemia\">https:\/\/www.gov.uk\/government\/news\/mhra-authorises-world-first-gene-therapy-that-aims-to-cure-sickle-cell-disease-and-transfusion-dependent-thalassemia<\/a><\/li>\n<li>FDA news release. FDA Approves First Gene Therapies to Treat Patients with Sickle Cell Disease. (8 December 2023).<br \/>\n<a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-gene-therapies-treat-patients-sickle-cell-disease\">https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-gene-therapies-treat-patients-sickle-cell-disease<\/a><\/li>\n<li>Feuerstein A. In historic decision, FDA approves a CRISPR-based medicine for treatment of sickle cell disease. STAT news. (8 December 2023).<br \/>\n<a href=\"https:\/\/www.statnews.com\/2023\/12\/08\/fda-approves-casgevy-crispr-based-medicine-for-treatment-of-sickle-cell-disease\/\">https:\/\/www.statnews.com\/2023\/12\/08\/fda-approves-casgevy-crispr-based-medicine-for-treatment-of-sickle-cell-disease\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base The recent UK and US approvals for gene therapy approaches to treat and potentially cure sickle-cell disease are remarkable scientific advances. [1, 2] They also come with prices of upwards of $2 million for a single &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-46957","post","type-post","status-publish","format-standard","hentry","category-other-news"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/46957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=46957"}],"version-history":[{"count":4,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/46957\/revisions"}],"predecessor-version":[{"id":46961,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/46957\/revisions\/46961"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=46957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=46957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=46957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}