{"id":47780,"date":"2024-05-27T10:09:45","date_gmt":"2024-05-27T10:09:45","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=47780"},"modified":"2024-05-30T16:31:47","modified_gmt":"2024-05-30T16:31:47","slug":"no-correlation-between-nasal-viral-load-and-severity-of-covid-19-in-large-vaccine-studies","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/47780","title":{"rendered":"No correlation between nasal viral load and severity of COVID-19 in large vaccine studies"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\" alignright\" src=\"https:\/\/i-base.info\/wp-content\/uploads\/2020\/03\/COVID-19-graphic.png\" width=\"231\" height=\"142\" \/>An open-access paper published in JAMA Network Open this week is notable for not finding any correlation between SARS-CoV-2 viral load in the nasopharynx and subsequent severity of COVID-19.<\/strong><\/p>\n<p>These are unexpected results \u2013 other studies have linked viral load to severity of symptoms \u2013 suggest caution in interpreting individual-level viral load as a surrogate for COVID-19 severity, especially given increasing diversity in preexisting immunity.<\/p>\n<p>This was a secondary analysis using data from the placebo participants in the four main international registrational vaccine studies. The results might be related to early timing of samples and\/or sample sites compared to viral load in plasma.<\/p>\n<p>The main significant association was a lower nasal viral load (by 0.5 log copies\/mL) in the Janssen study, although this could have been linked to differences in sample collection and handling compared to other RCTs.<\/p>\n<p>Reference<\/p>\n<p>Fisher LH et al. SARS-CoV-2 viral load in the nasopharynx at time of first infection among unvaccinated individuals: A secondary cross-protocol analysis of 4 randomized trials. JAMA Netw Open. 20247(5):e2412835. (24 May 2024).<br \/>\n<a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2819043\">doi:10.1001\/jamanetworkopen.2024.1283.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base An open-access paper published in JAMA Network Open this week is notable for not finding any correlation between SARS-CoV-2 viral load in the nasopharynx and subsequent severity of COVID-19. These are unexpected results \u2013 other studies &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[278],"tags":[],"class_list":["post-47780","post","type-post","status-publish","format-standard","hentry","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/47780","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=47780"}],"version-history":[{"count":11,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/47780\/revisions"}],"predecessor-version":[{"id":47791,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/47780\/revisions\/47791"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=47780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=47780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=47780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}