{"id":4820,"date":"2001-10-01T20:30:38","date_gmt":"2001-10-01T19:30:38","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=4820"},"modified":"2014-06-11T14:21:35","modified_gmt":"2014-06-11T14:21:35","slug":"respiratory-failure-in-pcp-patients-can-recur-after-haart-initiated","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/4820","title":{"rendered":"Respiratory failure in PCP patients can recur after HAART initiated"},"content":{"rendered":"<p><strong>Recurrence of acute respiratory failure is a threat when highly active antiretroviral therapy (HAART) is initiated early after the diagnosis of AIDS-inaugurating Pneumocystis carinii pneumonia (PCP), according to Parisian investigators.<\/strong><\/p>\n<p>Dr. Jacques Cadranel, of H\u00f4pital Tenon, and associates report that this phenomenon occurred in three patients out of 65 with PCP treated at a single centre between 1996 and 2000. The severe PCP, which in all three cases was the first sign of HIV infection, resolved after 15 days of parenteral cotrimoxazole and steroids.<\/p>\n<p>HAART was initiated within 1 to 16 days of PCP diagnosis. As reported in the American Journal of Respiratory and Critical Care Medicine for September 1, acute respiratory failure with high-grade fever developed within 7 to 17 days. Lung biopsies and bronchoalveolar lavage revealed severe nonspecific pulmonary inflammatory foci surrounding rare P. carinii cysts.<\/p>\n<p>HAART was interrupted in two patients and steroids were reintroduced in two. All three patients recovered from the respiratory failure.<\/p>\n<p>Dr. Cadranel&#8217;s team reports that HAART initiation led to marked decreases in plasma viral load, but that &#8220;circulating CD4+ cell counts did not increase in parallel, suggesting possible CD4+ cell sequestration in the lungs and their participation in the acute pulmonary reaction.&#8221;<\/p>\n<p>Reference:<\/p>\n<p>Wislez M et al. Acute Respiratory Failure Following HAART Introduction in Patients Treated for Pneumocystis carinii Pneumonia. Am J Respir Crit Care Med 2001;164:847-851.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11549544?dopt=Abstract\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11549544?dopt=Abstract<\/a><\/p>\n<p>Source: Reuters Health<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Recurrence of acute respiratory failure is a threat when highly active antiretroviral therapy (HAART) is initiated early after the diagnosis of AIDS-inaugurating Pneumocystis carinii pneumonia (PCP), according to Parisian investigators. Dr. Jacques Cadranel, of H\u00f4pital Tenon, and associates report that &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[31],"tags":[],"class_list":["post-4820","post","type-post","status-publish","format-standard","hentry","category-opportunistic-infections-coinfections-and-complications"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4820","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=4820"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4820\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=4820"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=4820"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=4820"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}