{"id":48348,"date":"2024-08-10T13:14:30","date_gmt":"2024-08-10T13:14:30","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=48348"},"modified":"2024-08-12T16:14:32","modified_gmt":"2024-08-12T16:14:32","slug":"sub-cutaneous-formulation-of-long-acting-cabotegravir-doesnt-meet-criteria-to-continue-development","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/48348","title":{"rendered":"Subcutaneous formulation of long-acting CAB\/RPV discontinued"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p><strong><a href=\"https:\/\/i-base.info\/htb\/wp-content\/uploads\/2024\/07\/IAS-logo-for-web2.png\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-48051 alignright\" src=\"https:\/\/i-base.info\/htb\/wp-content\/uploads\/2024\/07\/IAS-logo-for-web2-219x300.png\" alt=\"\" width=\"185\" height=\"250\" \/><\/a>A new subcutaneous (SC) formulation of long-acting cabotegravir and rilpivirine (CAB-LA\/RPV-LA) unfortunately turned out to have poorer tolerability compared to the current intramuscular (IM) gluteal injections.<\/strong><\/p>\n<p>Results were presented from a substudy in 93 participants in the phase 3 FLAIR study who were given three SC abdominal injections before returning to IM.<\/p>\n<p>Although plasma drug levels of cabotegravir and rilpivirine were generally comparable for both formulations, injection site reactions were more difficult to tolerate. This included nodules persisting for a median of 39 days compared to 9 days with IM.<\/p>\n<p>Although there were no virologic failures, five participants discontinued the substudy due to injection site reactions.<\/p>\n<p>Patient questionnaires reported significantly lower treatment acceptability and satisfaction with the SC formulation, although about one-third preferred the convenience of SC injections.<\/p>\n<p>These results led to ViiV discontinuing this SC formulation although the presenter emphasised that ViiV remains committed to further research that would enable self-administration.<\/p>\n<p>Reference<\/p>\n<p>D\u2019Amico R et al, Subcutaneous injections of cabotegravir + rilpivirine in virally suppressed adults with HIV-1: a substudy of the Phase 3 FLAIR study. AIDS 2024, 22\u201326 July 2024, Munich. Oral abstract OAB2604.<br \/>\n<a href=\"https:\/\/programme.aids2024.org\/Abstract\/Abstract\/?abstractid=1785\">https:\/\/programme.aids2024.org\/Abstract\/Abstract\/?abstractid=1785<\/a><\/p>\n<p>\n<\/p>","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base A new subcutaneous (SC) formulation of long-acting cabotegravir and rilpivirine (CAB-LA\/RPV-LA) unfortunately turned out to have poorer tolerability compared to the current intramuscular (IM) gluteal injections. Results were presented from a substudy in 93 participants in &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,3],"tags":[335],"class_list":["post-48348","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-antiretrovirals","tag-aids-25th-munich-2024"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/48348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=48348"}],"version-history":[{"count":7,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/48348\/revisions"}],"predecessor-version":[{"id":48385,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/48348\/revisions\/48385"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=48348"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=48348"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=48348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}