{"id":4919,"date":"2001-11-02T15:14:20","date_gmt":"2001-11-02T14:14:20","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/4919"},"modified":"2014-06-11T14:04:39","modified_gmt":"2014-06-11T14:04:39","slug":"daily-injection-more-effective-than-thrice-weekly-interferon-alpha-2b-for-hcvhiv","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/4919","title":{"rendered":"Daily injection more effective than thrice-weekly interferon alpha-2b for HCV\/HIV"},"content":{"rendered":"<p><strong>For patients co-infected with HIV and the hepatitis C virus (HCV), daily administration of interferon alpha-2b is more than twice as effective as the traditional three times\/week regimen in suppressing HCV loads. This finding was presented Friday at the Infectious Diseases Society of America&#8217;s 39th annual meeting in San Francisco.<\/strong><\/p>\n<p>A total of 180 such patients were randomly assigned to daily or thrice-weekly dosing with 3 mIU interferon-alpha-2b, plus 800 mg\/day oral ribavirin. More than 85% of subjects were also using highly active antiretroviral therapy.<\/p>\n<p>At 12 weeks, 31.6% of patients receiving daily injections had reductions in blood HCV levels to below the level of detection, compared with 12.1% of those receiving interferon three times\/week.<\/p>\n<p>&#8220;Because daily administration is more effective than the standard, this suggests that recently approved pegylated interferon will be a better choice for this population,&#8221; presenter Dr. Mark Sulkowski, of Johns Hopkins University in Baltimore, told Reuters Health. With the new preparation, he said, injections would be once a week, but blood interferon levels would be maintained at a level similar to those observed after once-daily injection.<\/p>\n<p>&#8220;An added plus was that neither regimen appeared to adversely affect any HIV parameters,&#8221; Dr. Sulkowski added.<\/p>\n<p>Source: Reuters Health<\/p>\n","protected":false},"excerpt":{"rendered":"<p>For patients co-infected with HIV and the hepatitis C virus (HCV), daily administration of interferon alpha-2b is more than twice as effective as the traditional three times\/week regimen in suppressing HCV loads. This finding was presented Friday at the Infectious &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-4919","post","type-post","status-publish","format-standard","hentry","category-hepatitis-coinfection"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4919","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=4919"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4919\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=4919"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=4919"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=4919"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}