{"id":4925,"date":"2001-11-02T16:44:31","date_gmt":"2001-11-02T15:44:31","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/4925"},"modified":"2014-06-11T14:05:29","modified_gmt":"2014-06-11T14:05:29","slug":"ccr5-density-on-t-cells-directly-correlates-with-hiv-disease-progression-2","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/4925","title":{"rendered":"CCR5 density on T cells directly correlates with HIV disease progression"},"content":{"rendered":"<p><strong>The number of CCR5 co-receptors expressed on the surface of CD4+ T cells modifies the decline in CD4+ cells in HIV-infected individuals, French investigators report.<\/strong><\/p>\n<p>Dr. Pierre Corbeau, from H\u00f4pital Saint Eloi in Montpellier, France, and colleagues previously showed that CCR5 density is correlated with HIV load. In a study described in the September 7th issue of AIDS, they investigated the relationship between CCR5 density and disease progression. The CCR5 densities of HIV-infected patients and healthy volunteers was determined.<\/p>\n<p>The CCR5 density on CD4+ T cells was stable over time in HIV-infected patients, the authors state. In a cohort of 25 asymptomatic and non-treated patients, annual CD4+ T cell loss was directly related to the CCR5 density on CD4+ T cells. This finding appeared to be independent of the CCR5 genotype, i.e., the presence or absence of the delta-32 deletion.<\/p>\n<p>Slow disease progressors had significantly lower CCR5 densities than non-slow progressors (p = 0.004) or control subjects (p = 0.002), the researchers note.<\/p>\n<p>&#8220;These results are compatible with the hypothesis that CCR5 density, which is a key factor of HIV-1 infectability, determines in vivo HIV production, and thereby the rate of CD4+ cell decline,&#8221; the authors note.<\/p>\n<p>Dr. Corbeau&#8217;s team believes that &#8220;CCR5 density quantitation could be a new valuable prognostic tool in HIV-1 infection.&#8221; In addition, &#8220;these data emphasize the therapeutic potential of treatments that reduce functional CCR5 density,&#8221; the investigators state.<\/p>\n<p>Reference:<\/p>\n<p>AIDS 2001;15:1627-1634.<\/p>\n<p>Source: Reuters Health<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The number of CCR5 co-receptors expressed on the surface of CD4+ T cells modifies the decline in CD4+ cells in HIV-infected individuals, French investigators report. Dr. Pierre Corbeau, from H\u00f4pital Saint Eloi in Montpellier, France, and colleagues previously showed that &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"class_list":["post-4925","post","type-post","status-publish","format-standard","hentry","category-basic-science-and-immunology"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4925","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=4925"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4925\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=4925"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=4925"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=4925"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}