{"id":49950,"date":"2025-01-02T17:30:57","date_gmt":"2025-01-02T17:30:57","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=49950"},"modified":"2025-02-07T01:50:36","modified_gmt":"2025-02-07T01:50:36","slug":"tecovirimat-news-continues-with-approval-in-japan-to-treat-mpox","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/49950","title":{"rendered":"Tecovirimat news continues: Japan approval includes mpox indication"},"content":{"rendered":"

Simon Collins, HIV i-Base<\/strong><\/p>\n

\"\"<\/a>On 2 January 2025, Siga Technologies announced that tecovirimat had been approved in Japan with a broad indication to treat orthopoxviruses including smallpox, mpox and cowpox. [1]<\/strong><\/p>\n

This news was unexpected given two large randomised mpox studies very recently reported no clinical benefits against mpox, with both studies being stopped early. [2]<\/p>\n

When the first of these studies was stopped in October 2024, Siga claimed that data might still support potential benefits, even though this was denied by the NIH. [3]<\/p>\n

comment<\/strong><\/h3>\n

As tecovirimat was licensed for mpox in the UK in 2022 and in the EU in 2023, with a caution about very limited data, the Japanese decision might just be late and might be reevaluated now. If this is the case then SIGA would be opportunistically issuing misleading information.<\/strong><\/p>\n

Given the changing recommendations over the use of tecovirimat in the management of mpox and the lack of clearly effective treatments, these differences need to be addressed publicly.<\/strong><\/p>\n

Both the PALM007 and STOMP studies were NIH funded and it is not acceptable that full results have not yet been made publicly available.<\/strong><\/p>\n

    \n
  1. Siga Technologies press release. TEPOXX (tecovirimat) Approved in Japan for the Treatment of Orthopoxviruses. (2 January 2025).
    \n    www.globenewswire.com\/news-release\/2025\/01\/02\/3003478\/9738\/en\/TEPOXX-tecovirimat-Approved-in-Japan-for-the-Treatment-of-Orthopoxviruses.html<\/a><\/li>\n
  2. Tecovirimat fails to show benefit in randomised STOMP study in mpox clade 2. HTB (10 December 2024).
    \n    i-base.info\/htb\/49733<\/a><\/li>\n
  3. Lack of tecovirimat activity against mpox clade 1. HTB (21 October 2024).
    \n    i-base.info\/htb\/49171<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Simon Collins, HIV i-Base On 2 January 2025, Siga Technologies announced that tecovirimat had been approved in Japan with a broad indication to treat orthopoxviruses including smallpox, mpox and cowpox. [1] This news was unexpected given two large randomised mpox …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[323],"tags":[],"class_list":["post-49950","post","type-post","status-publish","format-standard","hentry","category-mpox"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/49950","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=49950"}],"version-history":[{"count":9,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/49950\/revisions"}],"predecessor-version":[{"id":50231,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/49950\/revisions\/50231"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=49950"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=49950"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=49950"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}