{"id":51191,"date":"2025-05-29T14:07:21","date_gmt":"2025-05-29T14:07:21","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=51191"},"modified":"2025-07-21T10:47:33","modified_gmt":"2025-07-21T10:47:33","slug":"2025-update-of-the-drug-resistance-mutations-in-hiv-1","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/51191","title":{"rendered":"IAS-USA update drug resistance mutations (2025)"},"content":{"rendered":"

Simon Collins, HIV i-Base<\/strong><\/p>\n

This 2025 edition of the International Antiviral Society\u2013USA (IAS\u2013USA) drug resistance mutations list updates the November 2022 recommendations.<\/strong><\/p>\n

A summary of new\u00a0drug resistance includes several new mutations in integrase. See Table 1 below.<\/p>\n

Other changes include the addition of figure bars and user notes for the entry inhibitors fostemsavir and ibalizumab.<\/p>\n

Antiretroviral drugs that are no longer recommended or manufactured are now listed at the bottom of the drug class and are shaded in grey. Their user notes are retained for historical reference.<\/p>\n

Table 1. Summary of mutation updates to the 2025 figure bars.<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n
Drug<\/strong><\/td>\n\nFigure bar changes (mutation type)<\/strong>\n<\/td>\n<\/tr>\n
\nDoravirine\n<\/td>\nAdded A98G (minor)<\/td>\n<\/tr>\n
\nDolutegravir\n<\/td>\n\nAdded S147G (minor)\n<\/td>\n<\/tr>\n
\nCabotegravir\n<\/td>\n\nAdded L74I (major), but relevant for subtype A6 only.\n<\/td>\n<\/tr>\n
\nLenacapavir\n<\/td>\n\nAdded K70H (major)
\nUpdated K70N (major)
\nUpdated L56I (major)
\nUpdated N74D (major)\n<\/td>\n<\/tr>\n
\nRaltegravir\n<\/td>\n\nAdded G118R (major)
\nAdded G140C (minor)\n<\/td>\n<\/tr>\n
\nElvitegravir\n<\/td>\n\nAdded G118R (major)
\nAdded E138A\/K (minor)
\nAdded G140A\/C\/S (minor)\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

References<\/p>\n

    \n
  1. Wensing AM et al. 2025 Update of the Drug Resistance Mutations. Topics in HIV Medicine. Volume 33, Issue 2, (May 2025).
    \nhttps:\/\/www.iasusa.org\/wp-content\/uploads\/2025\/05\/33-2-457.pdf<\/a> (PDF)<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Simon Collins, HIV i-Base This 2025 edition of the International Antiviral Society\u2013USA (IAS\u2013USA) drug resistance mutations list updates the November 2022 recommendations. A summary of new\u00a0drug resistance includes several new mutations in integrase. See Table 1 below. Other changes include …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23,36],"tags":[],"class_list":["post-51191","post","type-post","status-publish","format-standard","hentry","category-guidelines","category-drug-resistance"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/51191","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=51191"}],"version-history":[{"count":2,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/51191\/revisions"}],"predecessor-version":[{"id":51962,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/51191\/revisions\/51962"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=51191"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=51191"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=51191"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}