{"id":5178,"date":"2009-10-02T20:51:06","date_gmt":"2009-10-02T19:51:06","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=5178"},"modified":"2013-08-16T10:35:06","modified_gmt":"2013-08-16T10:35:06","slug":"use-of-raltegravir-in-hiv-positive-transplant-recipients","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/5178","title":{"rendered":"Use of raltegravir in HIV-positive transplant recipients"},"content":{"rendered":"<p><a href=\"http:\/\/www.hiv-druginteractions.org\">www.hiv-druginteractions.org<\/a><\/p>\n<p><strong>Tricot and colleagues performed a retrospective review of the outcomes of 13 HIV-infected transplant patients treated with a raltegravir (RAL) and two nucleoside reverse transcriptase inhibitor (NRTI) regimen. Tolerability, ARV efficacy (plasma viral load, CD4 cell count), drug interactions, raltegravir pharmacokinetics and transplant outcome were assessed.<\/strong><\/p>\n<p>Thirteen patients with liver (n=8) or kidney (n=5) transplantation were included. RAL was initiated (400 mg twice daily) either at time of transplantation (n=6), or after transplantation (n=7). Median raltegravir trough concentration was 507 ng\/ml (range, 176-890), which is above the in vitro IC95 for wild type HIV-1 strains (15 ng\/ml). Target trough levels of tacrolimus or ciclosporin were obtained with standard doses. There were no episodes of acute rejection and HIV infection remained controlled. After a median follow-up of 9 months (range, 6-14), all patients were alive with satisfactory graft function.<\/p>\n<p>There was no evidence of an interaction between raltegravir and the immunosuppressants, and therefore, the use of a raltegravir + two NRTI-based regimen is a good alternative in HIV-infected patients undergoing solid organ transplantation.<\/p>\n<p>Source: www.hiv-druginteractions.org (July 2009)<\/p>\n<p><a href=\"http:\/\/www.hiv-druginteractions.org\/frames.asp?new\/Content.asp?ID=442\">http:\/\/www.hiv-druginteractions.org\/frames.asp?new\/Content.asp?ID=442<\/a><\/p>\n<p>Reference:<\/p>\n<p>TricotLetal.SafetyandefficacyofraltegravirinHIV-infectedtransplantpatientscotreatedwithimmunosuppressivedrugs.AmJTransplantation,Tricot L et al. Safety and efficacy of raltegravir in HIV-infected transplant patients cotreated with immunosuppressive drugs. Am J Transplantation, 2009, 9:1-7.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19519819\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19519819<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>www.hiv-druginteractions.org Tricot and colleagues performed a retrospective review of the outcomes of 13 HIV-infected transplant patients treated with a raltegravir (RAL) and two nucleoside reverse transcriptase inhibitor (NRTI) regimen. Tolerability, ARV efficacy (plasma viral load, CD4 cell count), drug interactions, &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-5178","post","type-post","status-publish","format-standard","hentry","category-pk-and-drug-interactions"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/5178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=5178"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/5178\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=5178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=5178"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=5178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}