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Simon Collins, HIV i-Base<\/strong><\/p>\n A fascinating and compelling review of the current understanding of the HIV viral reservoir and a brief history of the key research was given in a plenary talk by John Mellors from the University of Pittsburgh.<\/strong><\/p>\n This covered establishing the size of the reservoir (likely 10 x 10(11) cells with replicant-competent HIV in 1 million to 100 million), when and how these cells integrate and hide, with differences between men and women, and strategies to overcome the reservoir.<\/p>\n Recent studies have reported notable responses using monoclonal and autologous antibodies in order to delay or sustain HIV viral rebound off-ART, including in the RIO study. Predictors of responses include activation-induced CD8 markers with ELISpot immune parkers in the absence of circulating virus. Updated results from RIO were also presented at CROI this year. [2]<\/p>\n Next steps include more complicated multi-immune interventions and intensive dosing time schedules for example in ACTG 5374 and the UK AbVax studies that are both still enroling. [3, 4, 5, 6]<\/p>\n References<\/p>\n Simon Collins, HIV i-Base A fascinating and compelling review of the current understanding of the HIV viral reservoir and a brief history of the key research was given in a plenary talk by John Mellors from the University of Pittsburgh. …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,20,15],"tags":[346],"class_list":["post-53684","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-cure-research","category-basic-science-and-immunology","tag-croi-2026"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/53684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=53684"}],"version-history":[{"count":2,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/53684\/revisions"}],"predecessor-version":[{"id":53686,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/53684\/revisions\/53686"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=53684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=53684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=53684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n
\nhttps:\/\/www.croiwebcasts.org\/console\/player\/55147<\/a><\/li>\n
\nhttps:\/\/www.croiconference.org\/abstract\/1206-2026\/<\/a> (abstract)
\nhttps:\/\/www.croiwebcasts.org\/console\/player\/55099 (webcast)<\/li>\n
\nhttps:\/\/clinicaltrials.gov\/study\/NCT06071767<\/a><\/li>\n
\nhttps:\/\/actgnetwork.org\/article\/actg-announces-launch-of-clinical-trial-evaluating-combination-of-three-novel-immune-based-therapies-for-hiv-cure\/<\/a><\/li>\n
\nhttps:\/\/clinicaltrials.gov\/study\/NCT07054931<\/a><\/li>\n
\nhttps:\/\/www.abvaxstudy.org\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"