{"id":544,"date":"2008-08-30T16:52:22","date_gmt":"2008-08-30T15:52:22","guid":{"rendered":"http:\/\/localhost\/new\/htb\/?p=544"},"modified":"2013-08-27T16:13:54","modified_gmt":"2013-08-27T16:13:54","slug":"new-us-pediatric-dosing-for-lopinavirr","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/544","title":{"rendered":"New US pediatric dosing for lopinavir\/r"},"content":{"rendered":"<p><strong>The lopinavir\/r (Kaletra) tablet and oral solution labels were updated to include dosing recommendations for pediatric patients 14 days to 6 months of age and from 12 to 18 years of age.<\/strong><\/p>\n<p>Dosing in children (14 days &#8211; 18 years of age) is based on body weight or body surface area (size) see Table 1. For full details see the FDA announcement and new product information.<\/p>\n<p><strong>Table 1. Pediatric dosing recommendations for patients 6 months to 18 years of age<\/strong> *<\/p>\n<table>\n<tbody>\n<tr>\n<th>Body weight (kg)<\/th>\n<th>Body surface area (m<sup>2<\/sup>)<\/th>\n<th>Recommended number of 100\/25 mg tablets, twice daily<\/th>\n<\/tr>\n<tr>\n<td>15 to 25<\/td>\n<td>=0.6 to &lt;0.9<\/td>\n<td>2<\/td>\n<\/tr>\n<tr>\n<td>&gt;23 to 35<\/td>\n<td>=0.9 to &lt;1.4<\/td>\n<td>3<\/td>\n<\/tr>\n<tr>\n<td>&gt;35<\/td>\n<td>=1.4<\/td>\n<td>4 (or two 200\/50 mg tablets)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>* Based on body weight or body surface area for lopinavir\/r tablets (without concomitant efavirenz, neviraprine, fosamprenavir, or nelfinavir)<\/p>\n<p>Source: FDA list serve (23 June 2008).<a href=\"http:\/\/www.fda.gov\/oashi\/aids\/listserve\/listserve2008.html#62308\"><br \/>\nhttp:\/\/www.fda.gov\/oashi\/aids\/listserve\/listserve2008.html#62308<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The lopinavir\/r (Kaletra) tablet and oral solution labels were updated to include dosing recommendations for pediatric patients 14 days to 6 months of age and from 12 to 18 years of age. Dosing in children (14 days &#8211; 18 years &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-544","post","type-post","status-publish","format-standard","hentry","category-antiretrovirals"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/544","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=544"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/544\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=544"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=544"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=544"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}