{"id":571,"date":"2008-08-30T17:42:16","date_gmt":"2008-08-30T16:42:16","guid":{"rendered":"http:\/\/localhost\/new\/htb\/?p=571"},"modified":"2013-08-27T16:07:24","modified_gmt":"2013-08-27T16:07:24","slug":"renal-tubular-dysfunction-with-tenofovir-based-haart-in-four-vertically-infected-adolescents","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/571","title":{"rendered":"Renal tubular dysfunction with tenofovir-based HAART in four vertically infected adolescents"},"content":{"rendered":"<p><strong>Polly Clayden, HIV i-Base<\/strong><\/p>\n<p><strong>A poster authored by Onyeador and coworkers from Imperial College and St Mary&#8217;s Hospital, London described renal tubular dysfunction in four adolescents receiving tenofovir-based HAART.<\/strong><\/p>\n<p>This was a retrospective case note review of children &lt;18 years old who have ever received tenofovir. In this clinic, all children receiving tenofovir undergo prospective screening by annual renal ultrasound scanning (USS), three monthly serum electrolytes and urine Ca\/Cr, albumin\/Cr or protein\/Cr and retinal binding protein.<\/p>\n<p>In this cohort of 139 HAART experienced, vertically infected children, 51 (37%) had received tenofovir. Four (8%) patients, all female, had documented renal tubular leak at a median age of 16.9 years (range 12.3-18 years). The children&#8217;s ethnicity was: black african (2), caucasian (1) asian\/caucasian (1). None of the children had hepatitis B\/C coinfection, prior renal disease, family history of renal disease or hypertension.<\/p>\n<p>Their median duration of HAART prior to tenofovir-based HAART was 9 years (range 9-14 years), in three regimens (range 2-8 regimens). The tenofovir-based HAART was started at a median CD4 count of 335 cells\/mm<sup>3<\/sup> (range 20-1360 cells\/mm<sup>3<\/sup>) and median viral load 77,000 copies\/mL (~range 1,200-172,000 copies\/mL).<\/p>\n<p>The children all received the adult tenofovir dose of 300 mg once daily, at initial weights of 32, 33, 36 and 59 kg with a dose range of 5.1-9.4 mg\/kg for a median duration of 37 months (range 18-54 months) prior to stopping tenofovir. All children were asymptomatic, identified on screening, with biochemical resolution within 4 months of tenofovir cessation.<\/p>\n<p>The authors wrote: &#8220;Although unlicensed, tenofovir is widely used in HAART experienced paediatric cohorts resulting in cases of renal tubular dysfunction. Paediatric formulations and pharmacokinetic studies are currently recruiting with results eagerly awaited.&#8221;<\/p>\n<p class=\"ref\">Reference:<\/p>\n<p class=\"ref\">Onyeador N, Patel D, Lyall H et al. Renal tubular dysfunction associated with tenofovir based HAART in perinatally acquired HIV: the need for paediatric formulations and pharmacokinetic studies. 14th Annual BHIVA Conference, Dublin, 2008, HIV Medicine, 9 (Suppl. 1). P61.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Polly Clayden, HIV i-Base A poster authored by Onyeador and coworkers from Imperial College and St Mary&#8217;s Hospital, London described renal tubular dysfunction in four adolescents receiving tenofovir-based HAART. This was a retrospective case note review of children &lt;18 years &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,3],"tags":[50],"class_list":["post-571","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-antiretrovirals","tag-bhiva-14th-2008"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/571","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=571"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/571\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=571"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=571"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=571"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}