{"id":5754,"date":"2006-02-10T17:30:37","date_gmt":"2006-02-10T16:30:37","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=5754"},"modified":"2013-12-07T08:35:03","modified_gmt":"2013-12-07T08:35:03","slug":"low-rash-risk-with-efavirenz-after-nevirapine-rash","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/5754","title":{"rendered":"Low rash risk with efavirenz after nevirapine rash"},"content":{"rendered":"<p><strong>Mark Mascolini for NATAP.org<\/strong><\/p>\n<p><strong>Only 10 of 122 adults (8%) who replaced nevirapine with efavirenz because of rash had the same problem with the second nonnucleoside, Thai clinicians reported<\/strong> [2]<strong>. They could tease out no predictors of efavirenz-induced rash after a nevirapine rash.<\/strong><\/p>\n<p>Weerawat Manosuthi from the Ministry of Public Health in Nonthaburi and coworkers checked records of 122 people, 64 of them (52.5%) men, who had to stop nevirapine because of rash.<\/p>\n<p>These people started their nevirapine regimens with a low median CD4 count of 54 cells\/mm<sup>3<\/sup> (interquartile range 20 to 167 cells\/mm<sup>3<\/sup>). Seventy-six people (62%) dropped nevirapine because of diffuse maculopapular rash or urticaria, and 46 (38%) did so because of rash with constitutional symptoms, angioedema, serum sickness-like reactions, or Stevens Johnson syndrome.<\/p>\n<p>Another rash flared up in 10 people a median of 8 days (interquartile range 2.0 to 12.3 days) after the switch to efavirenz. Stevens Johnson syndrome arose in 1 person with a history of multiple drug allergies, while the other 9 had diffuse maculopapular rash of the trunk and limbs. All rashes cleared after indinavir\/ritonavir replaced efavirenz.<\/p>\n<p>Checking a laundry list of variables that may favor a second rash, the Thai team found none. Nonpredictive factors included age, gender, baseline CD4 count, baseline viral load, previous opportunistic infections, severity of nevirapine-induced rash, time between stopping nevirapine and starting efavirenz, and concurrent medications. The 10 people who got a second rash were slightly but not significantly older than those who did not (40.5 versus 36.5 years, P = 0.167).<\/p>\n<p>Source:<a href=\"http:\/\/www.natap.org\"> www.natap.org<\/a><\/p>\n<p>Reference:<\/p>\n<p>Manosuthi W, Thongyen S, Chumpathat N, et al. Prevalence and risk factors of rash from efavirenz in HIV-infected patients with preceding nevirapine-associated rash. 45th Interscience Conference on Antimicrobial Agents and Chemotherapy. December 16-29, 2005. Washington, DC. Abstract H-343.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mark Mascolini for NATAP.org Only 10 of 122 adults (8%) who replaced nevirapine with efavirenz because of rash had the same problem with the second nonnucleoside, Thai clinicians reported [2]. They could tease out no predictors of efavirenz-induced rash after &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,3],"tags":[100],"class_list":["post-5754","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-antiretrovirals","tag-icaac-45th-2005"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/5754","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=5754"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/5754\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=5754"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=5754"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=5754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}