{"id":6055,"date":"2009-12-30T11:19:30","date_gmt":"2009-12-30T10:19:30","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=6055"},"modified":"2013-08-05T05:39:31","modified_gmt":"2013-08-05T05:39:31","slug":"gemfibrozil-significantly-reduced-by-lopinavirr","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/6055","title":{"rendered":"Gemfibrozil significantly reduced by lopinavir\/r"},"content":{"rendered":"<p><strong>www.hiv-druginteractions.org<\/strong><\/p>\n<p><strong>This was an open label, single sequence study in 15 healthy volunteers comparing gemfibrozil pharmacokinetics parameters before and after two weeks of lopinavir\/ritonavir (400\/100 mg twice daily).<\/strong><\/p>\n<p>The GMR (90% CI) for gemfibrozil AUC after 14 days of lopinavir\/ritonavir compared with base line was 0.59 (0.52 to 0.67) (P&lt;0.001). GMR (90%CI) for gemfibrozil apparent oral clearance and Cmax were 1.69 (1.41 to 1.97) and 0.67 (0.49 to 0.86), respectively (P&lt;0.0001 and P&lt;0.01, respectively). There was no change in gemfibrozil half life.<\/p>\n<p>It is not clear what the mechanism is for the reduction in the systemic exposure of gemfibrozil. However, clinicians treating HIV-infected patients for hypertriglyceridemia should be aware of this interaction.<\/p>\n<p>Ref: Busse KH, Hadigan C, Chairez C, et al. Gemfibrozil concentrations are significantly decreased in the presence of lopinavir-ritonavir. J Acquir Immune Defic Syndr, 2009, 52(2): 235-239.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19648824\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19648824<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>www.hiv-druginteractions.org This was an open label, single sequence study in 15 healthy volunteers comparing gemfibrozil pharmacokinetics parameters before and after two weeks of lopinavir\/ritonavir (400\/100 mg twice daily). The GMR (90% CI) for gemfibrozil AUC after 14 days of lopinavir\/ritonavir &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-6055","post","type-post","status-publish","format-standard","hentry","category-pk-and-drug-interactions"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/6055","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=6055"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/6055\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=6055"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=6055"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=6055"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}