{"id":6129,"date":"2009-12-31T12:59:43","date_gmt":"2009-12-31T11:59:43","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=6129"},"modified":"2013-08-05T05:52:10","modified_gmt":"2013-08-05T05:52:10","slug":"lipodystrophy-is-common-in-children-from-three-european-cohorts","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/6129","title":{"rendered":"Lipodystrophy is common in children from three European cohorts"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p><strong>Researchers from 14 sites in Belgium, Poland and Italy reported the prevalence of lipodystrophy in a cohort of 468 children and adolescents (92% infected at birth). <\/strong><\/p>\n<p>Data collected included demographic and clinical history and used standardised assessment to determine fat loss or accumulation in the face, limbs, buttocks, breasts, neck and trunk.<\/p>\n<p>The cohort was evenly split by gender, with median age 13.5 years (IQR 9.9-17.0). Tanner puberty stage included 28% stage I and 34% stage V. In this group, 73% were white and 22% Black African. HIV treatment was used by 95% of the cohort for a median 8.8 years, with 62% having viral load suppressed &lt;50 copies\/mL. The median CD4% was 31% (IQR 24-38) and just over 300 children were currently asymptomatic.<\/p>\n<p>Assessment of symptoms was by clinician-completed questionnaire. Over 40% of children had at least one lipodystrophy symptom: 15% had just fat loss, 13% just fat accumulation (mostly trunk) and 13% had both symptoms. This group included 14 cases of severe fat accumulation and 11 cases of both severe fat loss and fat accumulation.<\/p>\n<p>In multivariate analysis, after controlling for duration of treatment, maternal lipodystrophy, maximal CDC status, and having ever used d4T, indinavir, d-drugs and efavirenz, significant associations were found for d4T use (AOR 4.23; 2.02, 8.85), efavirenz use (AOR=2.72; 1.36, 5.46), indinavir use (AOR 3.23) and clinical stage (AOR 3.30; 1.28, 8.02) and either fat loss or fat accumulation.<\/p>\n<p>Even stronger associations were found for children who had both symptoms.<\/p>\n<p>Maternal lipodystrophy was also associated with an adjusted OR of 3.01 (1.78, 5.57) for any symptom and 4.75 (1.60, 14.20) for both symptoms.<\/p>\n<p>Ref: Alam NM et al. Risk factors for body fat redistribution in a European cohort of HIV-infected children and adolescents. 11th Intl Workshop on Adverse Drug Reactions. 26-28 October 2009, Philadelphia. Poster abstract P-06. Antiviral therapy 2009; 14 Suppl 2: A27.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base Researchers from 14 sites in Belgium, Poland and Italy reported the prevalence of lipodystrophy in a cohort of 468 children and adolescents (92% infected at birth). Data collected included demographic and clinical history and used standardised &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,32],"tags":[125],"class_list":["post-6129","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-paediatric-care","tag-lipo-11th-2009"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/6129","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=6129"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/6129\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=6129"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=6129"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=6129"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}