{"id":6196,"date":"2001-12-09T19:13:35","date_gmt":"2001-12-09T18:13:35","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=6196"},"modified":"2014-06-11T13:32:43","modified_gmt":"2014-06-11T13:32:43","slug":"syncytium-inducing-viral-phenotype-halves-thymic-t-cell-production-in-children","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/6196","title":{"rendered":"Syncytium inducing viral phenotype halves thymic T cell production in children"},"content":{"rendered":"<p><strong>Graham McKerrow, HIV i-Base<\/strong><\/p>\n<p><strong>HIV-1-infected children with syncytium-inducing (SI) viral strains have CD4+ T cell counts and thymic output levels approximately half as high as those in children with non-SI (NSI) viral strains, according to a new study.<\/strong><\/p>\n<p>Researchers in Madrid, Spain, compared the thymic production of new T cells in 90 samples from HIV-1-infected children, average age 4.9 years. They also looked at CD4+ T cell levels in the children, and their correlation with thymic output.<\/p>\n<p>Children infected with SI viral strains had CD4+ T cell and thymic output levels approximately half as high as those observed in children with NSI viral strains (p &lt; 0.001). Moreover, these differences were independent of viral load (which was similar in the SI and NSI groups), patient age and treatment type, report Drs Rafael Correa and Angeles Munoz-Fernandez, of the Hospital General Universitario -Gregorio Maranon. &#8211;<\/p>\n<p>In three children followed prospectively, the switch from the NSI to the SI viral phenotype was followed by marked declines in both thymic output and CD4+ T cell levels.<\/p>\n<p>-These results suggest an inhibitory effect of SI viral phenotype on the production of new T cells, &#8211; the authors say in the October 19th issue of AIDS, -which is independent of viral load and viral replication kinetics. &#8211; This conclusion is consistent with prior studies indicating that T-tropic (SI) viruses but not M-tropic (NSI) viruses are capable of infecting immature thymocytes.<\/p>\n<p>&#8211; It is likely, &#8211; the investigators believe, &#8211; that disease progression in children, which is associated with the appearance of T-tropic viruses, could be due to the inhibition of thymic function produced by these viral strains, which would impede the recovery of lost CD4+ T cells. &#8211;<\/p>\n<p>-This fact, &#8211; they conclude, -provides an additional rationale to implement antiretroviral therapies that lead to undetectable viral load levels, even in children with severe CD4+ T cell depletion, with the goal of allowing an adequate thymic function to recover lost T cells. &#8211;<\/p>\n<p>Reference:<\/p>\n<p>Correa R, Munoz-Fernandez MA. Viral phenotype affects the thymic production of new T cells in HIV-1-infected children. AIDS 2001 Oct 19;15(15):1959-63.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=%09Retrieve&amp;db=PubMed&amp;list_uids=11600823&amp;dopt=Abstract\">http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd= Retrieve&amp;db=PubMed&amp;list_uids=11600823&amp;dopt=Abstract<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Graham McKerrow, HIV i-Base HIV-1-infected children with syncytium-inducing (SI) viral strains have CD4+ T cell counts and thymic output levels approximately half as high as those in children with non-SI (NSI) viral strains, according to a new study. Researchers in &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32],"tags":[],"class_list":["post-6196","post","type-post","status-publish","format-standard","hentry","category-paediatric-care"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/6196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=6196"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/6196\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=6196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=6196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=6196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}