{"id":6263,"date":"2002-01-09T23:21:17","date_gmt":"2002-01-09T22:21:17","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=6263"},"modified":"2014-06-05T14:31:05","modified_gmt":"2014-06-05T14:31:05","slug":"videx-ec-study-confirms-and-clarifies-dosing-on-an-empty-stomach","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/6263","title":{"rendered":"ddI EC (Videx) study confirms and clarifies dosing on an empty stomach"},"content":{"rendered":"<p><strong>Brian Boyle MD, for HIVandhepatitis.com<\/strong><\/p>\n<p><strong>The significance and importance of assuring that Videx EC (enteric coated ddI) is taken on an empty stomach were addressed in a poster presented at the 41st ICAAC that summarized four studies that were designed to assess the effect of food and timing of meals on the bioavailability of Videx EC.<\/strong><\/p>\n<p>The four studies involved a total of 334 patients and were open label, single dose, randomised, crossover studies conducted in healthy subjects. In these studies, 400mg of Videx EC was given with a high fat meal (757 calories), light meal (373 calories), yoghurt (69 calories), or applesauce (25 calories).<\/p>\n<p>The high-fat meal, light meal, yoghurt, and applesauce decreased the Cmax of Videx EC by 46%, 22%, 30%, and 24%, respectively, and lowered the AUC by 19%, 27%, 20%, and 18%, respectively. If the Videx EC was given 1 hour before a meal, Cmax and AUC were lower by 15% and 24%, respectively, and for 2 hours after a meal, were lower by 15% and 10%, respectively. For 1.5, 2, and 3 hours before meals, Cmax values were unchanged but AUC was lower by 10%, 4%, and 0%, respectively.<\/p>\n<p>There were no deaths or serious adverse events in the studies. These data reaffirm the current dosing recommendations regarding Videx EC: It appears that taking Videx EC at least 1.5 hours before or 2 hours after a meal are sufficient to achieve Videx EC concentrations equivalent to those achieved with fasting.<\/p>\n<p>Reference:<\/p>\n<p>B.D. Damle and others. Effect of Food on Oral Bioavailability of Didanosine from Delayed Release Capsules Containing Enteric Coated Beads. Abstract A-499.<\/p>\n<p>Source:<br \/>\n<a href=\"http:\/\/www.hivandhepatitis.com\">http:\/\/www.hivandhepatitis.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Brian Boyle MD, for HIVandhepatitis.com The significance and importance of assuring that Videx EC (enteric coated ddI) is taken on an empty stomach were addressed in a poster presented at the 41st ICAAC that summarized four studies that were designed &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,3],"tags":[96],"class_list":["post-6263","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-antiretrovirals","tag-icaac-41st-2001"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/6263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=6263"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/6263\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=6263"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=6263"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=6263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}