{"id":6374,"date":"2002-04-10T12:28:37","date_gmt":"2002-04-10T11:28:37","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=6374"},"modified":"2014-06-05T12:19:49","modified_gmt":"2014-06-05T12:19:49","slug":"controlling-pi-resistance-like-a-switch-mdr1-and-p-glycoprotein","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/6374","title":{"rendered":"Controlling PI resistance like a switch: MDR1 and p-glycoprotein"},"content":{"rendered":"<p><strong>One specific gene in a person\u2019s body could literally be a drug-resistance switch \u2014 it may turn on and off a person\u2019s ability to develop resistance to some protease inhibitors. GMHC Treatment Issues reports.<\/strong><\/p>\n<p>It\u2019s well understood that unwavering adherence to one\u2019s antiretroviral therapy (ART) regimen gives the best chance of keeping drug levels high enough to sustain suppression of viral replication and allow immune recovery to take root. Yet perfect performance is not a sure bet. Some people who never miss a dose fail to see their T-cells rise \u2014 even though their viral load stays within moderate levels. Others have all the luck: their virus goes undetectable and stays there for years while their CD4 counts hover near quadruple digits \u2014 all with side effects no more serious than occasional diarrhoea. Many clinicians have long thought that some genetic advantage must be at work, but there\u2019s been little proof and no way to tell who\u2019s drawn the lucky DNA.<\/p>\n<p><a href=\"http:\/\/www.thebody.com\/gmhc\/issues\/jan02\/gene.html\">http:\/\/www.thebody.com\/gmhc\/issues\/jan02\/gene.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>One specific gene in a person\u2019s body could literally be a drug-resistance switch \u2014 it may turn on and off a person\u2019s ability to develop resistance to some protease inhibitors. GMHC Treatment Issues reports. It\u2019s well understood that unwavering adherence &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[],"class_list":["post-6374","post","type-post","status-publish","format-standard","hentry","category-on-the-web"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/6374","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=6374"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/6374\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=6374"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=6374"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=6374"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}