{"id":6476,"date":"2002-05-11T13:19:36","date_gmt":"2002-05-11T12:19:36","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=6476"},"modified":"2014-06-05T12:00:50","modified_gmt":"2014-06-05T12:00:50","slug":"reduction-of-mother-to-child-hiv-1-transmission-breastfeeding-negates-benefits-of-short-course-regimens","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/6476","title":{"rendered":"Reduction of mother to child HIV-1 transmission: breastfeeding negates benefits of short course regimens"},"content":{"rendered":"<p><strong>\u2018Short course regimens to prevent mother-to-child transmission of HIV-1 in less-developed countries should be accompanied by interventions to minimise the risk of subsequent transmission via breastfeeding\u2019<\/strong><\/p>\n<p>Antiretrovirals and elective caesarean sections have successfully reduced mother-to-child HIV-1 transmission rates in the more-developed world. With limited resources in the less-developed world, short-course anti-retroviral regimens are the most feasible option to reduce transmission to a minimum. The Petra study team did a randomised controlled trial to assess the efficacy of different regimens with zidovudine and lamivudine in 1797 women. They report two regimens that were effective in reducing HIV-1 transmission up to week 6 after birth; however, the benefits had diminished considerably after 18 months of follow-up. These results emphasise the importance of including interventions to reduce the risk of vertical transmission via breastfeeding.<\/p>\n<p>In a Commentary (see below), Karen Beckerman adds that instead of inducing resistance to AIDS therapies, prophylaxis against mother-to-child transmission must be linked to preventing the creation of orphans.<\/p>\n<p>Source: The Lancet<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u2018Short course regimens to prevent mother-to-child transmission of HIV-1 in less-developed countries should be accompanied by interventions to minimise the risk of subsequent transmission via breastfeeding\u2019 Antiretrovirals and elective caesarean sections have successfully reduced mother-to-child HIV-1 transmission rates in the &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[],"class_list":["post-6476","post","type-post","status-publish","format-standard","hentry","category-pmtct-and-maternal-health"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/6476","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=6476"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/6476\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=6476"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=6476"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=6476"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}