{"id":6580,"date":"2002-07-11T18:27:53","date_gmt":"2002-07-11T17:27:53","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=6580"},"modified":"2014-06-05T11:15:57","modified_gmt":"2014-06-05T11:15:57","slug":"the-number-of-cd4-t-cells-infected-with-hiv-is-predictive-of-cd4cd8-ratio","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/6580","title":{"rendered":"The number of CD4+ T cells infected with HIV is predictive of CD4+:CD8+ ratio"},"content":{"rendered":"<p><strong>By Brian Boyle MD, for HIVandhepatitis.com<\/strong><\/p>\n<p><strong>Highly active antiretroviral therapy (HAART) can very dramatically decrease plasma viremia and improve CD4+ T cell counts. Despite these improvements, which may significantly improve patient morbidity and mortality, most individuals on HAART, even those with an undetectable plasma viral load, continue to have low-grade, ongoing HIV replication.<\/strong><\/p>\n<p>It has been speculated that this continued HIV replication may be responsible for chronically elevated levels of CD8+ T cells or abnormal CD4+:CD8+ T cell ratios observed in some patients on HAART, and data from a recent study from the National Institutes of Health (NIH) support this conclusion.<\/p>\n<p>In the study, published in The Journal of Infectious Diseases, the investigators at the NIH evaluated the relationship between CD4+:CD8+ T cell count ratios and the frequency of CD4+ T cells carrying HIV-1 proviral DNA and of HIV-specific cytotoxic CD8+ T lymphocytes (CTLs).<\/p>\n<p>The study enrolled 32 HIV-infected individuals who had been receiving HAART for &gt;2.5 years and in whom plasma viral load was &lt;50 copies\/mL. In these patients, the mean CD4+ and CD8+ T cell counts were 840 cells\/mm3 and 1110 cells\/mm3, respectively, and the CD4+:CD8+ T cell ratio was 0.90.<\/p>\n<h2>Results<\/h2>\n<p>The investigators found a statistically significant inverse correlation between the frequency of CD4+ T cells carrying HIV-1 proviral DNA and the CD4+:CD8+ T cell ratio in these individuals. No correlation was found between the frequency of HIV-1-specific cytotoxic CD8+ T lymphocytes and the CD4+:CD8+ T cell ratios in those individuals.<\/p>\n<p>The authors conclude, \u201cThese data suggest that persistent, low-level, ongoing viral replication, although not sufficient to maintain HIV-1-specific CTL responses, may explain, in part, why normalization of the CD4+:CD8+ T cell ratio is not achieved in some infected individuals successfully treated with HAART.\u201d<\/p>\n<p>Reference:<\/p>\n<p>Chun TW, Justement JS, Pandya P et al. Relationship between the Size of the Human Immunodeficiency Virus Type 1 (HIV-1) Reservoir in Peripheral Blood CD4+ T Cells and CD4+:CD8+ T Cell Ratios in Aviremic HIV-1-Infected Individuals Receiving Long-Term Highly Active Antiretroviral Therapy. J Infect Dis 2002 Jun 1;185(11):1672-1676<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov:80\/entrez\/query.fcgi?cmd= Retrieve&amp;db=PubMed&amp;list_uids=12023777\">http:\/\/www.ncbi.nlm.nih.gov:80\/entrez\/query.fcgi?cmd= Retrieve&amp;db=PubMed&amp;list_uids=12023777<\/a><\/p>\n<p>Copyright 2002 by HIV and Hepatitis.com. All Rights Reserved.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>By Brian Boyle MD, for HIVandhepatitis.com Highly active antiretroviral therapy (HAART) can very dramatically decrease plasma viremia and improve CD4+ T cell counts. Despite these improvements, which may significantly improve patient morbidity and mortality, most individuals on HAART, even those &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"class_list":["post-6580","post","type-post","status-publish","format-standard","hentry","category-basic-science-and-immunology"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/6580","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=6580"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/6580\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=6580"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=6580"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=6580"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}