{"id":7088,"date":"2005-09-14T01:52:03","date_gmt":"2005-09-14T00:52:03","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=7088"},"modified":"2014-03-31T17:15:54","modified_gmt":"2014-03-31T17:15:54","slug":"antiviral-activity-of-foscarnet-in-salvage-patients","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/7088","title":{"rendered":"Antiviral activity of foscarnet in salvage patients"},"content":{"rendered":"<p><strong>Mike Youle MD<\/strong><\/p>\n<p><strong>Foscarnet, a pyrophosphate analogue, continues to make a minor comeback for the treatment of HIV in late stage disease (CD4 &lt;100 cells\/mm<sup>3<\/sup>, HIV RNA &gt;50,000 copies\/mL, 3-class drug failure). Christine Katlama presented data on a group of salvage patients in whom she used an induction regimen of 5g iv bid for 6 weeks followed by a maintenance phase, if they achieved a &gt;1 log drop in viral load, of 5g iv bid for two days a week.<\/strong> [1]<\/p>\n<p>Katlama treated 11 patients in the induction phase and 6 reached maintenance, 2 patients died of HIV disease and lymphoma, only one patients stopped due to marked oedema. Viral load decline in the induction phase ranged from -0.1 log to -2.95 log with a median of -1.79 log at week 6 and a median CD4 increase of +50 cells\/mm<sup>3<\/sup>. Six patients started the maintenance phase but three had viral load failure whilst the other three reached &gt;24 weeks with a CD4 rise of +71 cells\/mm<sup>3<\/sup> and a HIV RNA below 6,000 copies\/mL. Further follow-up was curtailed by the availability of TMC114, which 7 patients commenced. Thus it appears that for extreme cases, foscarnet may be a useful tool to help patients survive until the next best agent(s) arrives in the clinic.<\/p>\n<p>Thiovir is an oral foscarnet analogue being developed by Adventrx Pharmaceuticals. An in vitro study of the agent against a panel of NRTI and NNRTI resistant strains of HIV showed good activity with synergy with AZTand a 2-fold better suppression than foscarnet. After 13 rounds of replication there was a five-fold increase in IC50 to both thiovir and foscarnet, this is certainly a drug to watch out for in the future.<\/p>\n<p>References:<\/p>\n<ol>\n<li>Katlama C, Canestri A, Wirden M et al. Foscarnet used in salvage therapy of multidrug resistant HIV-1 infected patients. 3rd IAS Conference on HIV Pathogenesis and Treatment, Rio de Janeiro, 2005. Abstract WePe12.9C16.<\/li>\n<li>Waninger S, Ramos S, Robbins J et al. Anti-HIV-1 activity of a foscarnet analogue, synergy with zidovudine and analysis of resistance variants selected in vitro. 3rd IAS Conference on HIV Pathogenesis and Treatment, Rio de Janeiro, 2005. Abstract TuPe6.1B16.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Mike Youle MD Foscarnet, a pyrophosphate analogue, continues to make a minor comeback for the treatment of HIV in late stage disease (CD4 &lt;100 cells\/mm3, HIV RNA &gt;50,000 copies\/mL, 3-class drug failure). Christine Katlama presented data on a group of &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,3],"tags":[91],"class_list":["post-7088","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-antiretrovirals","tag-ias-3rd-2005"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/7088","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=7088"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/7088\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=7088"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=7088"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=7088"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}