{"id":7230,"date":"2005-07-14T08:59:52","date_gmt":"2005-07-14T07:59:52","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=7230"},"modified":"2014-05-21T17:25:04","modified_gmt":"2014-05-21T17:25:04","slug":"risk-of-death-in-uk-after-diagnosis-of-3-class-resistance","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/7230","title":{"rendered":"Risk of death in UK after diagnosis of 3-class resistance"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p><strong>An analysis from Deenan Pillay on behalf of the UK Collaborative HIV Cohort Study (UK-CHIC) evaluated predictors of survival after diagnosis with multi-drug resistance (MDR). Of 628 patients 54 (9%) died within two years of their MDR diagnosis, defined as at least one primary mutation to nucleosides, NNRTIs and PIs. The cohort was 85% male, median age 43, with a median CD4 at MDR diagnosis of 238 cells\/mm3 (IQR 110-376). This rose to 13% at three years. though far fewer patients had this length of follow-up.<\/strong><\/p>\n<p>The study was primarily looking at response to strategies including staying on the same treatment, switching to a treatment with the same, higher, or lower genotypic sensitivity score (GSS) or stopping treatment (with the same or a reduced GSS). Compared to staying on the same treatment, switching to a regimen with a lower GSS score increased the risk of death (RR 1.4 [0.17, 13.0]) while switching to a regimen with a high GSS (RR 0.31, [0.11, 0.89]) or even the same GSS (RR 0.35, [0.16, 0.80]) was protective.<\/p>\n<p>There are several important factors to remember when looking at these results. Firstly, the majority of patients with 2-year follow-up in this cohort were diagnosed with MDR between in 1999, 2000 or 2001 (26% 29% and 20% respectively). The subsequent period was therefore prior to the availability to T-20 and tipranavir. The analysis didn\u0092t look at role of individual drugs used in either the maintained or switched combinations, nor the effect of several changes in treatment.<\/p>\n<p>Although success rates to treatment are generally improving, a small percentage are likely to accumulate resistance, and this study provided a sobering reminder of the clinical impact of resistance. Prevalence of MDR in the UK is steady at 4% of patients, although the increasing number of people on treatment mean that absolute numbers are increasing.<\/p>\n<p>Reference:<\/p>\n<p>Grover D, Allen L, Pillay D et al. Predictors of death, and response to therapy in patients with multi(three)-class drug resistant HIV in the UK. 14th International HIV Drug Resistance Workshop (14th IHDRW), 7-11 June 2005, Quebec City, Canada.\u00a0Abstract 5. Antiviral Therapy 2005; 10:S7.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base An analysis from Deenan Pillay on behalf of the UK Collaborative HIV Cohort Study (UK-CHIC) evaluated predictors of survival after diagnosis with multi-drug resistance (MDR). Of 628 patients 54 (9%) died within two years of their &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,36],"tags":[111],"class_list":["post-7230","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-drug-resistance","tag-idrw-14th-2005"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/7230","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=7230"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/7230\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=7230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=7230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=7230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}