{"id":7591,"date":"2005-03-29T14:27:27","date_gmt":"2005-03-29T13:27:27","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=7591"},"modified":"2014-05-22T14:53:36","modified_gmt":"2014-05-22T14:53:36","slug":"responses-to-tb-treatment-in-hiv-positive-and-hiv-negative-patients-in-the-uk","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/7591","title":{"rendered":"Responses to TB treatment in HIV positive and HIV negative patients in the UK"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p><strong>A interesting case note review of patients at the Royal Free Hospital in London compared 115 people with active HIV\/TB coinfection to 114 unselected HIV negative TB patients treated over the same time period to study the adverse events profile when both HAART and \u00a0TB medication are used simultaneously.<\/strong><\/p>\n<p>TB coinfection is a increasing concern in many UK clinics, particularly in late presenters with advanced HIV disease (CD4 &lt;100 cells\/mm<sup>3<\/sup>), requiring specialist care management.<\/p>\n<p>Ronan Breen and colleagues found that anti-TB medication had a similar adverse event profile in both groups and that although HAART was associated with an increase in such events these did not lead to more treatment interruptions.<\/p>\n<p>Median duration of TB treatment was 6 months (range 3-36 months) and HAART was started a median of 2 months after TB treatment (range 0-7 months). Three quarters of the HIV positive patients received additional HIV treatment at some point. Rifamycin-based regimens were used in 98% cases.TB treatment was interrupted in 13 HIV positive and 10 HIV negative patients, largely due to hepatic toxicity (8 cases in each group). Other grade 3\/4 side effects were higher in the HIV-positive group: peripheral neuropathy 14% vs 4%; rash 10% vs 3%; persistent vomiting 9% vs 3% but this did not result in increased interruption of TB medication. HAART was stopped in 6\/84 (7%) patients due to poor adherence (2); treatment failure (3), IRIS (1), and 15 regimens were modified, largely to duce toxicity.<\/p>\n<p>Importantly, a higher proportion of coinfected patients than HIV negative patients successfully completed their course of TB treatment (110\/115 vs 99\/114).<\/p>\n<p>Reference:<\/p>\n<p>Breen R, Miller R, Ballinger J et al. Similar profile of adverse events during treatment for tuberculosis in patients with and without HIV co-infection. 7th ICDTHI,14-18 Nov, 2004, Glasgow. Abstract PL9.3.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base A interesting case note review of patients at the Royal Free Hospital in London compared 115 people with active HIV\/TB coinfection to 114 unselected HIV negative TB patients treated over the same time period to study &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,37],"tags":[83],"class_list":["post-7591","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-tb-coinfection","tag-hiv-7-glasgow-2004"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/7591","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=7591"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/7591\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=7591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=7591"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=7591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}