{"id":760,"date":"2008-06-12T20:19:48","date_gmt":"2008-06-12T19:19:48","guid":{"rendered":"http:\/\/localhost\/new\/htb\/?p=760"},"modified":"2013-08-28T07:01:42","modified_gmt":"2013-08-28T07:01:42","slug":"effect-of-100mg-ritonavir-once-and-twice-daily-on-lipids-and-cardiovascular-markers-in-hiv-negative-volunteers","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/760","title":{"rendered":"Effect of 100mg ritonavir once- and twice-daily on lipids and cardiovascular markers in HIV-negative volunteers"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p><strong>Carl Fletcher presented results from a study from the Chelsea and Westminster Hospital looking at the short-term impact of low-dose ritonavir on lipids, CD36 and other vascular inflammation markers (VIM) in 20 HIV-negative volunteers. The study looked at the relationship between drug exposure and these parameters.<\/strong><\/p>\n<p>Twenty HIV-negative volunteers (10 men and 10 women) were randomised volunteers to receive 100 mg ritonavir either once-daily (OD) or twice-daily (BID) for 14 days, and then, after a short wash-out period, switched to the alternative dose for a further 14 days. Median age and BMI were 28 years (range 19-45) and 22 kg\/m2 (range 18-26).<\/p>\n<p>CD36 is a receptor with a role in cholesterol accumulation and atherosclerosis pathogenesis, that is upregulated by some PIs including full-dose ritonavir. PIs can decrease monocyte CD36 levels in HIV-positive patients. Vascular markers were hsCRP, sICAM-1 and sCD40L. Lipid parameters included TC, HDL, LDL and TG.<\/p>\n<p>They reported significant decreases in HDL and CD36 expression for OD and BID dosing (see Table 1) but only a significant increase in triglycerides with the BID dose. No changes in hs-CRP and VIM were observed. Drug levels showed a wide range of inter-patient variability, but there was a significant correlation between RTV plasma exposure and the change in TG and HDL (r = 0.34, p = 0.030 and r = 0.33, p = 0.040, all subjects).<\/p>\n<p><strong>Table 1: Ritonavir exposure and impact on lipids and other markers<\/strong><\/p>\n<table border=\"0\">\n<tbody>\n<tr>\n<th><\/th>\n<th>100mg RTV OD<\/th>\n<th>100mg RTV BID<\/th>\n<\/tr>\n<tr>\n<td>AUC (ng.h\/mL) median (range)<\/td>\n<td>5773 (2,466-18,848)<\/td>\n<td>14525 (6,862-46,370)<\/td>\n<\/tr>\n<tr>\n<td>Cmax (ng\/mL) median (range)<\/td>\n<td>751 (298-1896)<\/td>\n<td>1431 (597-3,874)<\/td>\n<\/tr>\n<tr>\n<td>HDL change<\/td>\n<td>-6% (p = 0.010)<\/td>\n<td>10% (p &lt; 0.001)<\/td>\n<\/tr>\n<tr>\n<td>CD36 change<\/td>\n<td>-14% (p = 0.012)<\/td>\n<td>-16% (p = 0.006)<\/td>\n<\/tr>\n<tr>\n<td>TG change<\/td>\n<td>NS<\/td>\n<td>+32% (p = 0.044)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>This study was also presented at the Retrovirus conference in Boston in February.<\/p>\n<p class=\"ref\">Reference:<\/p>\n<p class=\"ref\">Fletcher C et al. Plasma exposure of 100mg once (OD) and Twice (BID) decreases HDL and CD36 expression but only BID dosing increases triglycerides: potential impact of RTV on cardiovascular disease. Oral abstract 16.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base Carl Fletcher presented results from a study from the Chelsea and Westminster Hospital looking at the short-term impact of low-dose ritonavir on lipids, CD36 and other vascular inflammation markers (VIM) in 20 HIV-negative volunteers. The study &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[50],"class_list":["post-760","post","type-post","status-publish","format-standard","hentry","category-conference-reports","tag-bhiva-14th-2008"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/760","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=760"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/760\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=760"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=760"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}