{"id":765,"date":"2008-06-12T20:32:38","date_gmt":"2008-06-12T19:32:38","guid":{"rendered":"http:\/\/localhost\/new\/htb\/?p=765"},"modified":"2013-08-28T07:00:38","modified_gmt":"2013-08-28T07:00:38","slug":"use-of-fibroscan-as-non-invasive-alternative-to-liver-biopsy-in-hcvhiv-coinfection","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/765","title":{"rendered":"Use of fibroscan as non-invasive alternative to liver biopsy in HCV\/HIV coinfection"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p><strong>Rodger and colleagues from the Royal Free presented results from the use of FirboScan in 30 HIV-positive patients with chronic liver disease related to HBV, HCV, alcohol and steotosis.<\/strong><\/p>\n<p>Liver fibrosis was evaluated using the METAVIR scoring system. Fibroscan measures of &lt;7.9 Kpa were used as the cut off for no or minimal fibrosis (F0\/1) and &gt;11.9Kpa as the cut off for severe fibrosis (F4).<\/p>\n<p>Twelve patients had liver biopsy scores of F0\/1 and 16 had scores of F3\/4.<\/p>\n<p>Stiffness was significantly correlated to stage of fibrosis (r = 0.68, P &lt; 0.0001). Median values for F0\/F1 were 5.6 Kpa (range 3.6\u009610.2) and for F4, 14.3 Kpa (range 7.8\u009667.9). Patients with cirrhosis (F4) were detected with a positive predictive value (PPV) of 75% and a negative predictive value (NPV) of 91%. For moderate or severe fibrosis (&gt;F2) a cut off of &gt;7.9 Kpa gave a PPV of 92% and a NPV of 76%. Minimal fibrosis (F0\/F1) was detected with a PPV of 61% and a NPV of 92%.<\/p>\n<p>The authors concluded that FibroScan is a reliable method for the diagnosis of significant fibrosis (&gt;F2) and cirrhosis (F4) in HIV-positive patients with chronic liver disease, although further research is needed to inform its use in monitoring over time.<\/p>\n<p class=\"ref\">Reference:<\/p>\n<p class=\"ref\">Rodger A et al. Assessment of staging of liver fibrosis by transient elastography in HIV-positive patients with chronic liver disease using liver biopsy as the gold standard. Poster 72.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base Rodger and colleagues from the Royal Free presented results from the use of FirboScan in 30 HIV-positive patients with chronic liver disease related to HBV, HCV, alcohol and steotosis. Liver fibrosis was evaluated using the METAVIR &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,24],"tags":[50],"class_list":["post-765","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-hepatitis-coinfection","tag-bhiva-14th-2008"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/765","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=765"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/765\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=765"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=765"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=765"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}