{"id":7691,"date":"2005-01-31T08:29:30","date_gmt":"2005-01-31T07:29:30","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=7691"},"modified":"2014-05-22T15:13:13","modified_gmt":"2014-05-22T15:13:13","slug":"hcv-coinfection-linked-to-discontinuing-art-due-to-toxicity","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/7691","title":{"rendered":"HCV coinfection linked to discontinuing ART due to toxicity"},"content":{"rendered":"<p><strong>Graham McKerrow, HIV i-Base<\/strong><\/p>\n<p><strong>A European study of 1052 patients starting ART since 1999 found that those with HIV\/HCV coinfection were more likely to discontinue all or part of their ART regimens due to toxicity and patient\/physician choice than were HIV-positive patients without HCV. Moorcroft and colleagues in the EuroSIDA study group conclude that managing adverse events must remain a key intervention in maintaining HAART.<\/strong><\/p>\n<p>The study found that a year after starting ART, 65% of patients were still on their original regimen, 28% had changed and 7% had stopped treatment. The most common reason for discontinuation was toxicities (31%).<\/p>\n<p>The incidence of discontinuation decreased over time by 18% per year (95% CI 11\u201324%, p&lt;0.0001). The main decline was among patients who discontinued due to toxicities and patient\/physician choice. Patients with HCV had a higher incidence of discontinuation due to toxicities and patient\/physician choice during the first 6 months of ART (incidence rate ratio (IRR) 2.14, 95% CI 1.05\u20135.92, p=0.035) or after 6 months on therapy (IRR 2.09; 95% CI 1.02\u20134.28, p=0.044) compared to patients without HCV.<\/p>\n<p>Reference:<\/p>\n<p>Moorcroft A, Phillips AN, Soriano V et al. Why do patients with HIV stop antiretrovirals used as part of an initial highly active antiretroviral regimen? 6th Lipodystrophy Workshop (6th IWADRLH), Washington. <a href=\"http:\/\/www.aegis.org\/conferences\/lipo\/2004\/74.html\">Abstract 74<\/a>. Antiviral Therapy 2004; 9:L44.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Graham McKerrow, HIV i-Base A European study of 1052 patients starting ART since 1999 found that those with HIV\/HCV coinfection were more likely to discontinue all or part of their ART regimens due to toxicity and patient\/physician choice than were &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,24],"tags":[127],"class_list":["post-7691","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-hepatitis-coinfection","tag-lipo-6th-2004"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/7691","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=7691"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/7691\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=7691"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=7691"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=7691"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}