{"id":7693,"date":"2005-01-31T08:31:23","date_gmt":"2005-01-31T07:31:23","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=7693"},"modified":"2014-05-22T15:12:51","modified_gmt":"2014-05-22T15:12:51","slug":"improvement-of-lipids-following-switch-to-tenofovir","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/7693","title":{"rendered":"Improvement of lipids following switch to tenofovir"},"content":{"rendered":"<p><strong>Graham McKerrow, HIV i-Base<\/strong><\/p>\n<p><strong>Switching patients with virologically controlled HIV infection to a simplified maintenance ARV regimen results in an improved lipid profile, according to the preliminary findings of a French randomised, multicentre trial of 143 patients.<\/strong><\/p>\n<p>Despite low lipid levels at baseline, switching to a tenofovir (Viread) based combination can mildly decrease total and LDL-cholesterol and significantly reduce triglycerides, according to Merci\u00e9 and colleagues. They assessed the benefits of switching patients who had been on NNRTI- or PI-based HAART for &gt;6 months and had viral load (VL) &lt;50 copies\/mL to either efavirenz+tenofovir or efavirenz+tenofovir+3TC.<\/p>\n<p>Mean age was 42 +\/-10 years, 72% men and 28% women. Mean HAART duration at baseline was 3.7+\/-1.9 years.<\/p>\n<p>Median total and LDL cholesterol reduced from 5.3 mmol\/l and 3.4 mmol\/l by -0.4 and -0.3 respectively, both NS (p~0.20); HDL did not change. Median triglycerides reduced from 1.4 mmol\/l at baseline by -0.4 (p&lt;0.004).<\/p>\n<p>There were four serious adverse events (suicide attempt, pneumonia, dizziness and hepatic cytolysis), with two discontinuations. Only one patient had VL&gt;50 copies\/ml (69 copies\/ml at week 48). CD4 count increased by +23 (median CD4+ of 475\/mm3 at baseline).<\/p>\n<h3>Comment<\/h3>\n<p><strong>Although these results have generated interest related to the dual therapy maintenance arm it is unclear why this 48-week study merited an interim analysis and presentation at 36 weeks. The study continues and final results including lipodystrophy (evaluated by DEXA and CT) will be reported in 2005.<\/strong><\/p>\n<p>Reference:<\/p>\n<p>Merci\u00e9 P, Trylesinski A, Cabi\u00e9 A et al. Improvement in lipid profile in HIV-infected virologically controlled patients switched to a simple QD regimen: Preliminary results of the COOL trial evaluating EFV\/TDF vs EFV\/TDF\/3TC. 6th Lipodystrophy Workshop (6th IWADRLH), Washington, 2004. Abstract 82. Antiviral Therapy 2004; 9:L48.<br \/>\n<a href=\"http:\/\/www.aegis.org\/DisaplayConf\/?Abstract=87204\">http:\/\/www.aegis.org\/DisaplayConf\/?Abstract=87204\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Graham McKerrow, HIV i-Base Switching patients with virologically controlled HIV infection to a simplified maintenance ARV regimen results in an improved lipid profile, according to the preliminary findings of a French randomised, multicentre trial of 143 patients. Despite low lipid &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,8,27],"tags":[127],"class_list":["post-7693","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-side-effects","category-weight-diabetes-metabolic-complications","tag-lipo-6th-2004"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/7693","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=7693"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/7693\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=7693"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=7693"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=7693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}