{"id":7697,"date":"2005-01-31T08:34:02","date_gmt":"2005-01-31T07:34:02","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=7697"},"modified":"2014-05-22T15:12:03","modified_gmt":"2014-05-22T15:12:03","slug":"indinavir-impairs-endothelial-function-without-insulin-resistance","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/7697","title":{"rendered":"Indinavir impairs endothelial function without insulin resistance"},"content":{"rendered":"<p><strong>Graham McKerrow, HIV i-Base<\/strong><\/p>\n<p><strong>Treatment for 4 weeks with indinavir (IDV, Crixivan) monotherapy markedly impairs endothelial function and insulin-mediated vasodilation, without significant impairment of whole-body glucose disposal, according to an American study. So it appears unlikely that insulin resistance plays a major role in the induction of endothelial dysfunction.<\/strong><\/p>\n<p>Dub\u00e9 and colleagues hypothesised that IDV-induced endothelial dysfunction occurred because of IDV-induced insulin resistance. Their study assessed insulin sensitivity, endothelial function, and insulin-mediated vasodilation in 16 lean, healthy, male subjects before and after 4 weeks of IDV 800mg TID.<\/p>\n<p>Subjects were 37+\/-3 years old, with BMI of 25+\/-1 kg\/m<sup>2<\/sup>, body fat of 19.6+\/-1.9%, total cholesterol: 171+\/-8 mg\/dL; LDL-cholesterol: 98+\/-7 mg\/dl; HDL-cholesterol: 50+\/-4 mg\/dl; triglycerides: 140+\/-39 mg\/dl, and resting leg blood flow (LBF) of 0.207+\/-0.015 l\/min. There was no significant change in any of these parameters after IDV. Plasma adiponectin levels increased after IDV (16.4+\/-2.2 ug\/ml pre-IDV, 19.1+\/-2.3 ug\/ml post-IDV, p&lt;0.05). Normal, robust endothelium-dependent and insulin-mediated vasodilatory responses were present at baseline. After IDV, there was a marked blunting of endothelium-dependent vasodilation (258+\/-43% pre-IDV vs 60+\/-13% post, p&lt;0.05) and insulin-mediated vasodilation (70+\/-10% pre-IDV vs 16+\/-6% post, p&lt;0.05). In spite of these dramatic effects on vascular function, there was no significant change in the steady-state whole body glucose-disposal rate with IDV (8.0+\/-0.6 mg\/kg\/min pre-IDV vs 7.5+\/-0.6 post, p=NS).<\/p>\n<p>Reference:<\/p>\n<p>Dub\u00e9 MP, Shankar SS, Considine RV et al. Marked impairment of endothelial function without insulin resistance in healthy men treated with the HIV-1 protease inhibitor indinavir. 6th Lipodystrophy Workshop (6th IWADRLH), Washington, 2004. Abstract 95. Antiviral Therapy 2004; 9:L55.<br \/>\n<a href=\"http:\/\/www.aegis.org\/DisaplayConf\/?Abstract=87265\">http:\/\/www.aegis.org\/DisaplayConf\/?Abstract=87265\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Graham McKerrow, HIV i-Base Treatment for 4 weeks with indinavir (IDV, Crixivan) monotherapy markedly impairs endothelial function and insulin-mediated vasodilation, without significant impairment of whole-body glucose disposal, according to an American study. So it appears unlikely that insulin resistance plays &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,3],"tags":[127],"class_list":["post-7697","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-antiretrovirals","tag-lipo-6th-2004"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/7697","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=7697"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/7697\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=7697"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=7697"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=7697"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}