{"id":7710,"date":"2005-01-31T08:43:13","date_gmt":"2005-01-31T07:43:13","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=7710"},"modified":"2014-05-22T15:09:41","modified_gmt":"2014-05-22T15:09:41","slug":"25-patients-take-kaletra-on-an-empty-stomach-dietary-advice-often-missed-at-centre-of-excellence","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/7710","title":{"rendered":"25% patients take Kaletra on an empty stomach: dietary advice often missed at &#8216;centre of excellence&#8217;"},"content":{"rendered":"<p><strong>Graham McKerrow, HIV i-Base<\/strong><\/p>\n<p><strong>A retrospective questionnaire\/interview study of 63 patients taking lopinavir\/ritonavir (LPV\/r, Kaletra) at the Chelsea and Westminster Hospital in London found that only 43% were taking the drug with adequate food and just over a quarter of patients were taking Kaletra on an empty stomach.<\/strong><\/p>\n<p>Phillpot and colleagues aimed to interview a quarter of the clinics 500-odd patients taking an LPV\/r-containing regimen by telephone questionnaire or at a routine clinic visit. In fact, only 63 (12.5%) patients were interviewed. 38 (60%) said they were told to eat with LPV\/r, 20 (32%) said they weren\u2019t given any information and 5 (8%) couldn\u2019t remember.<\/p>\n<p>A moderate fat meal (500-682 kcals) increases mean lopinavir AUC and Cmax by 48% and 23% respectively relative to fasting, and this increased bioavailability is why Kaletra is recommended in prescription advice to be taken with food.<\/p>\n<p>The researchers comment: \u201cFor those patients who said they were given guidance on how to take Kaletra, a greater percentage took it with the correct amount of food. However patient error must be considered when carrying out retrospective questionnaires and dietary recall.\u201d<\/p>\n<p>Reference:<\/p>\n<p>Phillpot MN, Kabaroff E and Visser TL. Are patients given adequate dietary information when starting on a Lopinavir\/Ritonavir containing HAART regimen? 6th Lipodystrophy Workshop (6th IWADRLH), Washington, 2006. Abstract 86. Antiviral Therapy 2004; 9:L50.<br \/>\n<a href=\"http:\/\/www.aegis.org\/DisaplayConf\/?Abstract=87200\">http:\/\/www.aegis.org\/DisaplayConf\/?Abstract=87200\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Graham McKerrow, HIV i-Base A retrospective questionnaire\/interview study of 63 patients taking lopinavir\/ritonavir (LPV\/r, Kaletra) at the Chelsea and Westminster Hospital in London found that only 43% were taking the drug with adequate food and just over a quarter of &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,3],"tags":[127],"class_list":["post-7710","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-antiretrovirals","tag-lipo-6th-2004"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/7710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=7710"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/7710\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=7710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=7710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=7710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}