{"id":8534,"date":"2006-09-09T22:45:01","date_gmt":"2006-09-09T22:45:01","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=8534"},"modified":"2013-12-06T16:42:52","modified_gmt":"2013-12-06T16:42:52","slug":"atazanavirr-monotherapy-and-cns-penetration","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/8534","title":{"rendered":"Atazanavir\/r monotherapy and CNS penetration"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p><strong>Vernazza and colleagues presented results looking at the compartmental effect of reducing treatment to ritonavir-boosted atazanavir monotherapy in 30 patients (28 male) suppressed to &lt;50 copies\/mL on triple therapy.<\/strong><\/p>\n<p>HIV viral load was measured every 4 weeks, and semen and cerebro-spinal fluid (CSF) samples were obtained from consenting patients at baseline (semen) and week 24 (semen+CSF). The primary endpoint was defined as 2 consecutive viral load values &gt;400 copies\/mL.<\/p>\n<p>One patient failed monotherapy at week 8 who was retrospectively shown to have previously failed a PI based HAART. One patient prematurely terminated treatment at week 20. All remaining 27 patients had suppressed viral load &lt;100 copies\/mL at week 24. 22 patients still remain on ATV\/r with a median follow-up of 19 months (6 \u009629) and a mean CD4 increase of 78 cells\/mL.<\/p>\n<p>Nineteen CSF samples were obtained at week 24. Of these, three patients had detectable HIV-RNA in CSF (2.2, 2.9, 3.8 log copies\/mL) despite fully suppressed HIV-RNA in blood. All three CSF samples were wild type. Viral load was undetectable in all semen samples (n=15).<\/p>\n<p>The authors concluded \u0093limited penetration of PI into CNS may result in replication of wild-type HIV in the CNS in a relevant subset of patients. As the consequence of low-level HIV replication in different compartments is not known, future monotherapy trials should include careful monitoring of compartments other than blood. Mono-maintenance, however, might be a valid option for future studies.\u0094<\/p>\n<p>Reference:<\/p>\n<p>Vernazza P, Daneel S, Schiffer V et al. Risk of CNS-compartment failure on PI monotherapy (ATARITMO-study). XVI International AIDS Conference, Toronto, Canada.13-18 August 2006.\u00a0Poster abstract WEPE0073.<br \/>\n<a href=\"http:\/\/www.iasociety.org\/Default.aspx?pageId=11&amp;abstractId=2198350\">http:\/\/www.iasociety.org\/Default.aspx?pageId=11&amp;abstractId=2198350<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base Vernazza and colleagues presented results looking at the compartmental effect of reducing treatment to ritonavir-boosted atazanavir monotherapy in 30 patients (28 male) suppressed to &lt;50 copies\/mL on triple therapy. HIV viral load was measured every 4 &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,3],"tags":[151],"class_list":["post-8534","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-antiretrovirals","tag-aids-16th-toronto-2006"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/8534","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=8534"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/8534\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=8534"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=8534"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=8534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}