{"id":8863,"date":"2004-11-06T02:55:03","date_gmt":"2004-11-06T02:55:03","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=8863"},"modified":"2014-05-22T16:35:52","modified_gmt":"2014-05-22T16:35:52","slug":"clinical-features-and-predictors-of-survival-in-patients-with-aids-related-non-hodgkins-lymphoma","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/8863","title":{"rendered":"Clinical features and predictors of survival in patients with AIDS-related non-Hodgkin\u2019s lymphoma"},"content":{"rendered":"<p><strong>HIVandHepatitis.com<\/strong><\/p>\n<p><strong>In this study, Australian researchers analysed the clinical features and predictors of survival for AIDS-related non-Hodgkin\u2019s lymphoma (NHL) in the era of HAART, compared to earlier in the HIV epidemic.<\/strong><\/p>\n<p>All AIDS-NHL cases diagnosed at three inner Sydney hospitals caring for people with AIDS during 1985-2001 were identified through medical record searches. Demographic, clinical, immunological and histopathological information was recorded. Year of NHL diagnosis was grouped into three periods, corresponding to whether monotherapy (1985-1991), dual therapy (1992-1995) or HAART (1996-2001) was the main treatment for HIV infection. Statistical comparisons were made between the pre-HAART and post-HAART eras.<\/p>\n<p>Three hundred cases of AIDS-NHL were identified. Divergent trends were identified for systemic and primary central nervous system (CNS) NHL. For systemic NHL, the CD4+ T cells count at NHL diagnosis increased markedly to 208 cells\/mm3 in the post-HAART era (P=0.014) and there was a trend towards presentation as the first AIDS-defining illness (69%, P=0.053), and as earlier stage NHL disease (42%, P=0.048). Median survival time increased from 4.2 months in 1985-1991 to 19 months in the post-HAART era (P&lt;0.001).<\/p>\n<p>In a multivariate model, predictors of poor survival from systemic NHL included: NHL diagnosis after another AIDS-defining illness (P&lt;0.001), stage 4 NHL (P&lt;0.001), presentation at extra lymphatic sites (P=0.001), and non-receipt of chemotherapy (P=0.002).<\/p>\n<p>After adjusting for the factors, those diagnosed in the era of HAART had a significant 56% reduction in rate of death (P&lt;0.001). In contrast, for CNS NHL, clinical features were little changed and survival did not improve in the era of HAART.<\/p>\n<p>The study concluded that systemic NHL is presenting earlier in the course of HIV disease, and at a less advanced NHL stage. There has been a marked improvement in survival in the era of HAART even after adjustment for other prognostic variables. In contrast, primary CNS NHL remains a disease that presents late in the course of HIV infection and is associated with a very poor prognosis.<\/p>\n<p>Source: HIVandHepatitis.com<\/p>\n<p>\u00a9 Copyright 2004 by HIV and Hepatitis.com. All Rights Reserved. Reproduction for personal or educational use is encouraged and does not require permission. Written permission is required to re-print copyrighted articles but is almost always granted (email\u00a0<a href=\"mailto:publisher@HIVandHepatitis.com)\">publisher@HIVandHepatitis.com)<\/a>.<\/p>\n<p><a href=\"http:\/\/www.hivandhepatitis.com\/recent\/malignancies\/092404_f.html\">http:\/\/www.hivandhepatitis.com\/recent\/malignancies\/092404_f.html<\/a><\/p>\n<p>Reference:<\/p>\n<p>Robotin MC et al. Clinical features and predictors of survival of AIDS-related non-Hodgkin\u2019s lymphoma in a population-based case series in Sydney, Australia. HIV Medicine 5(5): 377-384. September 2004.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>HIVandHepatitis.com In this study, Australian researchers analysed the clinical features and predictors of survival for AIDS-related non-Hodgkin\u2019s lymphoma (NHL) in the era of HAART, compared to earlier in the HIV epidemic. All AIDS-NHL cases diagnosed at three inner Sydney hospitals &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[31,18],"tags":[],"class_list":["post-8863","post","type-post","status-publish","format-standard","hentry","category-opportunistic-infections-coinfections-and-complications","category-cancer-and-hiv"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/8863","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=8863"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/8863\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=8863"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=8863"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=8863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}